Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-190-2 | CAS number: 92-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20.-23.03.1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FDA guideline (§ 1500.41, Fed. Reg. Vol. 38, No. 187, p. 27019, 1973)
- GLP compliance:
- no
- Remarks:
- conducted prior to GLP guideline implementation
Test material
- Reference substance name:
- 3-hydroxy-4'-methoxy-2-naphthanilide
- EC Number:
- 202-190-2
- EC Name:
- 3-hydroxy-4'-methoxy-2-naphthanilide
- Cas Number:
- 92-79-5
- Molecular formula:
- C18H15NO3
- IUPAC Name:
- 3-hydroxy-4'-methoxy-2-naphthanilide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG breeding colony
- Strain: SPF-Albino-Himalayan, Hoe HIMK(SPFWiga)
- Weight at study initiation: 1,5 - 2,0 kg
- Housing: single cage
- Diet: ERKA 8300, ad libitum
- Water: tap water, ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped intact and clipped scarified
- Vehicle:
- other: propandiol 1,2
- Controls:
- not required
- Amount / concentration applied:
- 0.5 g mixed with 0.6 ml propandiol 1,2
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h after beginning of treatment
- Number of animals:
- 6
- Details on study design:
- 0.5 g of the test substance mixed with 0.6 ml propandiol 1,2 and placed on a square gauze patch, 2,5 x 2,5 cm of size, was applied on a clipped/intact and clipped/scarified skin of the albino rabbit. The patches were fixed by an adhesive tape and additionally covered by a neutral, impermeable PVC film. The entire trunk of the animal was then wrapped with an elastic bandage. After 24 hours of exposure the patches were removed and the reactions were examined. Follw-up examinations were made 48 h and 72 h after beginning of treatment.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: mean of 24, 48, 72 h after beginning of treatment
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h after beginning of treatment (end of observation)
- Remarks on result:
- other: shaved intact
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: mean of 24, 48, 72 h after beginning of treatment
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not relevant because of lacking effects
- Remarks on result:
- other: shaved intact
- Irritant / corrosive response data:
- In view of the shortened observation period and the slightness of effects a full recovery is expected in the case of a prolonged observation period of 14 days according to effective guidelines.
- Other effects:
- no other effects reported
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification acc. to (EC) 1272/2008: not irritating
This conclusion is legitimate even though the applied testing regime differs from today's standard methods. Since the test conditions were more stringent than required by OECD TG 404 (i.e. 24 h treatment, occlusive coverage, and scarified skin instead of 4 h treatment, semi-occlusive coverage, and intact skin) the test results are considered adequate to fulfill the endpoint requirements. - Executive summary:
The test material was tested for skin irritancy according to FDA guideline. Both intact and scarified skin sites of six rabbits were exposed to 0.5 g test substance for 24 h under occlusive conditions and the skin responses were examined at 24, 48, and 72 h after beginning of treatment. Mean values of the 24, 48 and 72 h readings were calculated for each animal. Only slight effects (erythema mean score: <=1, edema mean score: 0) below the threshold for classification were determined for the intact skin. All effects were fully reversible or expected to be fully reversible. Similar results were obtained for scarified skin. Based on these findings the test material was judged not to be irritating to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)