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Diss Factsheets
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EC number: 212-686-0 | CAS number: 846-48-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No data available.
Additional information
No data available.
Short description of key information:
No data available.
Effects on developmental toxicity
Description of key information
There is no developmental toxicity study with boldenone (ZK 5320) available. However, the result of a teratogenicity study is cited in RTECS database (May 2010):
Subcutaneous (rat, 17.-20. day of pregnancy): TDLo: 20 mg/kg (17-20D preg)
(Advances in the Biosciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1967- v. 13, p. 71, 1974 (AVBIB9))
Additional information
There is no developmental toxicity study with boldenone (ZK 5320) available. However, the result of one teratogenicity study is cited in RTECS database (May 2010):
Daily subcutaneous application of boldenone to female rats on day 17 to 20 of pregnancy results in abnormalities of the fetal urogenital system. (Advances in the Biosciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1967- v. 13, p. 71, 1974 (AVBIB9))
Toxicity to reproduction: other studies
Additional information
No data available.
Justification for classification or non-classification
Only very limited information on the reproduction toxicity of boldenone (ZK5320) is available. As other anabolic steroids, boldenone has an androgenic activity and long-term uptake of pharmacological doses can result in masculisation, cyclus abnormalities, and impaiment of fertility in women. In men the endogenous hormon production may be impaired, together with disturbed fertility (reduced spermatogenesis). The exposure during pregnancy can result in masculinization of the sexual organs of female fetusses in the womb. When boldenone is taken up by the nursing mother, it may be absorbed with the mothermilk and the development during infancy may be impaired.
Classified according to German legislation (TRGS-905) as Repr. (F) Cat. 1 and Repr. (E) Cat. 2 (EEC criteria).
Classified as Category 1B according toRegulation (EC) 1272/2008 (CLP).
According to the Directive 67/548/EEC, boldenone is classified:
Category 1; R60 - May impair fertility.
Category 2; R61 - May cause harm to the unborn child.
R64 - May cause harm to breastfed babies
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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