Registration Dossier
Registration Dossier
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EC number: 611-390-2 | CAS number: 56467-43-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12.03.2010 to 28.04.2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- adopted April 13, 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- May 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- 4-(Methacryloyloxy)bezophenone: 97.26%
Benzophenone acetate: 1.95 % - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.6
- Temp.:
- 25 °C
- pH:
- ca. 7
- Conclusions:
- The logarithmic partition coefficient (n-octanol/water) of the test item was determined to be 3.6 using the HPLC method at 25 °C +/- 1 °C.
- Executive summary:
The n-Octanol / water partition coefficient (log Kow) of 4 -(Methacryloyloxy)benzophenone is reported to be 3.6 at 25 °C according to OECD guideline 117, adopted 13 April 2004, andEU Method A.8, 30 May 2008; HPLC method).
Reference
Capacity Factor k' and log Powof the Reference Items
Item |
Replicate of analysis |
Retention time1 [min] |
Capacity factor2 |
Log K2 |
Log Pow3 |
Natriumnitrat |
3 |
0.593 |
n.a. |
n.a. |
n.a. |
Reference items: |
|
|
|
|
|
Methyl benzoate |
3 |
2.615 |
3.4 |
0.533 |
2.1 |
Atrazine |
3 |
2.615 |
3.4 |
0.533 |
2.6 |
Benzophenone |
3 |
4.362 |
6.4 |
0.803 |
3.2 |
Phenyl benzoate |
3 |
6.618 |
10.2 |
1.007 |
3.6 |
Benzyl benzoate |
3 |
8.479 |
13.3 |
1.124 |
4.0 |
Phenanthrene |
3 |
24.548 |
40.4 |
1.607 |
4.5 |
1Mean value of three measurements
2Values represent rounded results calculated from the exact raw data
3Log Pow values given in OECD Guideline No. 117
The linearity of the analytical method was confirmed in the log Pow-range from 2.1 to 4.5.
Calibration Curve: y = 0.4393 * x – 0.5299 (DIN 32645)
Regression Coefficient (r): 0.9574
Capacity Factor k’ and log Powof the Test Item 4 -(Methacryloyloxy)bezophenone
Test item |
Retention time1 [min] |
Capacity factor2 |
Log K2 |
Log Pow3 |
|
7.562 |
11.76 |
1.07 |
3.6 |
|
7.540 |
11.72 |
1.07 |
3.6 |
|
7.512 |
11.67 |
1.07 |
3.6 |
Mean value |
7.538 |
11.72 |
1.07 |
3.6 |
Description of key information
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.6
- at the temperature of:
- 25 °C
Additional information
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