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Diss Factsheets
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EC number: 287-502-5 | CAS number: 85536-20-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP status not known, near guideline study, published in peer reviewed literature, minor restrictions in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicological properties of hydrocarbon solvents
- Author:
- Hine CH, Zuidema HH
- Year:
- 1 970
- Bibliographic source:
- Industrial Medicine 39, 215-200.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test substance was applied to intact and abraded skin of 6 shaved rabbits. The application sites were covered in gauze for 24 hours. Skin irritation was assessed using the Draize numerical scoring system at 24 and 72 hours.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- mixed xylenes
- IUPAC Name:
- mixed xylenes
- Reference substance name:
- Xylene
- EC Number:
- 215-535-7
- EC Name:
- Xylene
- Cas Number:
- 1330-20-7
- Molecular formula:
- C8H10
- IUPAC Name:
- xylene
- Details on test material:
- C-8 aromatics (ortho, meta and para xylene; ethyl benzene; composition not defined). Boiling Range 138-141C.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Male rabbits 2-3 kg body weight.
Test system
- Type of coverage:
- other: gauze
- Preparation of test site:
- other: shaved, intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- not stated
- Duration of treatment / exposure:
- not stated
- Observation period:
- 24 and 72 hours
- Number of animals:
- 6
- Details on study design:
- A maximum of 4 samples was applied to each rabbit.
Comment: guideline methodology would require 4 hour semi-occluded contact.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 2.21
- Reversibility:
- no data
- Remarks on result:
- other: mean score for erythema and oedema for both intact and abraded skin
- Irritation parameter:
- erythema score
- Remarks on result:
- other: mean score for erythema and oedemafor both intact and abraded skin
- Irritant / corrosive response data:
- All six rabbits were affected on both intact and abraded skin. Individual scores ranged from 1 to 4.
Applicant's summary and conclusion
- Interpretation of results:
- other: moderately irritating
- Remarks:
- Criteria used for interpretation of results: other: primary irritation index descriptive rating
- Conclusions:
- Mixed xylene (C-8 aromatics) was a possible borderline skin irritant in this study.
- Executive summary:
Mixed xylenes (C-8 aromatics) were applied to the intact and abraded skin of six shaved rabbits. Application areas were covered with gauze for 24 hours and readings for skin irritation, according to the method of Draize, were made at 24 and 72 hours. Mixed xylenes were found to be moderately irritating under these conditions, with a Primary Dermal Irritation Index of 2.21.
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