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EC number: 236-293-9 | CAS number: 13283-01-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: Entry of the Agency for Toxic Substances and Disease Registry
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Toxicological profile for Tungsten
- Author:
- Keith S. et al.
- Year:
- 2 005
- Bibliographic source:
- Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test material
- Reference substance name:
- Tungsten hexachloride
- EC Number:
- 236-293-9
- EC Name:
- Tungsten hexachloride
- Cas Number:
- 13283-01-7
- Molecular formula:
- Cl6W
- IUPAC Name:
- tungsten hexachloride
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Details on dermal exposure:
- Single application of a 5 % Tungsten hexachloride solution
- Doses:
- 100, 200 and 1000 mg/kg bw
- No. of animals per sex per dose:
- 2 rabbits per dose group
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- other: LOAEL
- Effect level:
- 200 mg/kg bw
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 100 - < 200 mg/kg bw
- Mortality:
- In the high and mid dose all animals died after dosing. No deaths in the low dose group.
Any other information on results incl. tables
No information was located regarding mechanisms involved in absorption of tungsten through the skin. However, a report of death in rabbits following a single dermal application of a 5% tungsten chloride solution (Dow Chemical Company 1982) is evidence of absorption and systemic distribution of dermally applied tungsten.
Relatively little information is available concerning adverse effects in animals following acute-duration dermal exposure to tungsten. Contact dermatitis was reported in rabbits following dermal application of a 5% tungsten chloride solution in single doses ≥100 mg/kg; doses ≥200 mg/kg also resulted in death (Dow Chemical Company 1982). Instillation of a 5% tungsten chloride solution into the rabbit eye resulted in initial ocular irritation that resolved within 14 days postinstillation (Dow Chemical Company 1982).
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- No LD50 value can be determined based on this publication.
- Executive summary:
A publication of the Dow Chemical Company (1982) on the toxicological properties of Tungsten hexachloride was citied in the report of the Agency for Toxic Substances and Disease Registry (2005) on the “Toxicological profile for Tungsten”. In this study two rabbits per dose group were dermally exposed to a 5 % solution of Tungsten hexachloride in absolute doses of 100, 200 and 1000 mg/kg body weight. While all animals died in the high and mid dose groups, the animals of the low dose developed contact dermatitis. An LD50 value can not be calculated based on these data. When instilled to the eye the 5% solution of Tungsten hexachloride caused temporary ocular irritation.
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