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Diss Factsheets
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EC number: 209-294-7 | CAS number: 565-80-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
- Principles of method if other than guideline:
- In rabbit eye irritation test 0.1 mL of the undiluted test substance was applied to the eye of 6 rabbits followed by a 14 day observation period. In three eyes a washing was performed one hour after dosing. The other three eyes remained unwashed. Effects were scored as slight, moderate, strong and severe. In addition fluorescein staining was performed. The test was performed according to internal method TA 150.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,4-dimethylpentan-3-one
- EC Number:
- 209-294-7
- EC Name:
- 2,4-dimethylpentan-3-one
- Cas Number:
- 565-80-0
- Molecular formula:
- C7H14O
- IUPAC Name:
- 2,4-dimethylpentan-3-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in report): 2,4-Dimethylpentanon-3 / Diisopropyl keton
- Physical state: liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test substance( as cited in report): 2,4-Dimethyl-3-pentanone
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- - Weight at study initiation: not determined
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- Three out of six dosed eyes were washed after 1 hour.
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): In 3/6 eyes with distilled water
- Time after start of exposure: 1 hour
SCORING SYSTEM:
Eyes were scored for Initial, Conjunctiva, Lids, Nictating membrane, Cornea opacity, Iris score, Adnexal stain, Corneal stain and discharge.
Effects were rated Slight, Moderate or Strong.
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Remarks:
- Overall result
- Remarks on result:
- other: See irritant/corrosive response data
- Irritant / corrosive response data:
- The test article mostly caused slight erythema and moderate edema of the adnexa in unwashed eyes one hour after administration. By 24 hours, two of three unwashed eyes appeared clinically normal, and signs of irritation were restricted to slight erythema in the third eye. Immediate washing was palliative. Signs of irritation in washed eyes one hour after dosing were restricted to slight edema and slight erythema of the adnexa, with the exception of moderate erythema of the conjunctiva in a single eye. All washed and unwashed eyes appeared normal by 48 hours after dosing.
Any other information on results incl. tables
Overview of results as reported in study report:
Results |
3 unwashed eyes |
||||||
IMMED |
1 HR |
24 HR |
48 HR |
72 HR |
DAY 7 |
DAY 14 |
|
Initial |
Slt. |
|
|
|
|
|
|
Conjuctiva |
|
Mod. |
Slt. |
|
|
|
|
Lids |
|
|
|
|
|
|
|
Nict. Membrane |
|
Mod. |
Slt. |
|
|
|
|
Corneal Opacity |
|
|
|
|
|
|
|
Iris |
|
|
|
|
|
|
|
Adnexal Stain |
|
|
0/3 |
|
|
|
|
Corneal Stain |
|
|
0/3 |
|
|
|
|
Discharche |
|
Slt. |
|
|
|
|
|
Number Normal |
0 |
0 |
2 |
3 |
3 |
|
|
Results |
3 washed eyes |
||||||
IMMED |
1 HR |
24 HR |
48 HR |
72 HR |
DAY 7 |
DAY 14 |
|
Initial |
Slt. |
|
|
|
|
|
|
Conjuctiva |
|
Slt. |
Slt. |
|
|
|
|
Lids |
|
|
|
|
|
|
|
Nict. Membrane |
|
Slt. |
Slt. |
|
|
|
|
Corneal Opacity |
|
|
|
|
|
|
|
Iris |
|
|
|
|
|
|
|
Adnexal Stain |
|
|
0/3 |
|
|
|
|
Corneal Stain |
|
|
0/3 |
|
|
|
|
Discharche |
|
|
|
|
|
|
|
Number Normal |
0 |
0 |
2 |
3 |
3 |
|
|
Key: Slt. = Slight, Mod. = Moderate, Str. =Strong
No. Responding |
Slight |
Moderate |
Strong |
Severe |
Fluorescein Stain |
|
Adnexa |
Cornea |
|||||
Unwashed eyes |
3/3 |
|
|
|
0/3 |
0/3 |
Washed eyes |
3/3 |
|
|
|
0/3 |
0/3 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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