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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Bioaccumulation: aquatic / sediment

BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical 2,4-Pyridinedicarboxylic acid (CAS No. 499 -80 -9). The bioconcentration factor (BCF) of 2,4-Pyridinedicarboxylic acid was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical 2,4-Pyridinedicarboxylic acid is not expected to bioaccumulate in the food chain.

Additional information

Bioaccumulation: aquatic / sediment

Various predicted data for the target compound 2,4-Pyridinedicarboxylic acid(CAS No. 499-80-9) and supporting weight of evidence study for its structurally similar read across substance were reviewed for the bioaccumulation end point which are summarized as below:

 

In aprediction done using theBCFBAF Program(v3.01)of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical 2,4-Pyridinedicarboxylic acid (CAS No. 499 -80 -9). The bioconcentration factor (BCF) of 2,4-Pyridinedicarboxylic acid was estimated to be 3.162 L/kg whole body w.w (at 25 deg C).

 

In an another prediction done by using Bio-concentration Factor (v12.1.0.50374) moduleACD (Advanced Chemistry Development)/I-Lab predictive module, 2017), theBCFover the entire pH scale (pH 1 -14) of the test substance 2,4-Pyridinedicarboxylic acid (CAS no. 499 -80 -9) was estimated to be 1.

 

Bioconcentration Factor (BCF) of test chemical 2,4-Pyridinedicarboxylic acid was estimated using Chemspider database(ChemSpider, 2017). The bioconcentration factor of test substance 2,4-Pyridinedicarboxylic acid was estimated to be 1 at both pH 5.5 and 7.4, respectively.

 

Another predicted data was estimated usingSciFinder database (American Chemical Society (ACS), 2017) was used for predicting the bioconcentration factor (BCF) of test chemical2,4-Pyridinedicarboxylic acid (CAS No. 499 -80 -9).The bioconcentration factor (BCF) of 2,4-Pyridinedicarboxylic acid was estimated to be 1 (at 25 deg C).

 

From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application)  V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test substance 2,4-Pyridinedicarboxylic acid was estimated to be 5.52 dimensionless . The predicted BCF result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance 2,4-Pyridinedicarboxylic acid is non-bioaccumulative in nature.

 

In a supporting weight of evidence study from authoritative database (J-CHECK, 2017 and EnviChem, 2014) for the read across chemical 2,5-Pyridinedicarboxylic acid (CAS no. 100-26-5),bioaccumulation experiment was conducted on test organism Cyprinus carpiofor 6 weeks for evaluating the bioconcentration factor (BCF value) of 2,5-Pyridinedicarboxylic acid. Cyprinus carpio was used as a test organism for the study. Test chemical nominal conc. used for the study were2mg/land 0.2mg/l, respectively. Range finding study involve the TLm (48 hr) ˃ 1000 mg/l (w/v) on Rice fish (Oryzias latipes). Lipid content of the test organism Cyprinus carpio was determined to be4.1%. The bioconcentration factor (BCF value) of substance 2,5-Pyridinedicarboxylic acid on Cyprinus carpio was determined to be in the range of 0.3-0.9 L/Kg at a conc. of 2 mg/l and 2.9-8.6 L/Kg at a conc. of 0.2 mg/l, respectively.

 

For the read across chemical 2,3-Pyridinedicarboxylic acid (CAS no. 89-00-9),bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of read across chemical 2,3-Pyridinedicarboxylic acid (HSDB, 2017). The bioaccumulation factor (BCF) value was calculated using a water solubility of 11000 mg/l and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of 2,3-Pyridinedicarboxylic acid in fish was determined to be 3 dimensionless.

 

On the basis of above results for target chemical2,4-Pyridinedicarboxylic acid(from EPI suite, ACD labs,ChemSpider and CompTox Chemistry Dashboard,  2017) and for its read across substance from authoritative database (HSDB, J-CHECK and EnviChem), it can be concluded that the BCF value of test substance2,4-Pyridinedicarboxylic acidranges from 1 – 5.52 which does not exceed the bioconcentration threshold of 2000, indicating that the chemical2,4-Pyridinedicarboxylic acidis not expected to bioaccumulate in the food chain.