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EC number: 219-660-8 | CAS number: 2492-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and OECD Guideline study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
[Please provide information for all of the points below. Indicate if further information is included as attachment to the same record, or elsewhere in the dataset (insert links in 'Cross-reference' table)]
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
[Describe why the read-across can be performed (e.g. common functional group(s), common precursor(s)/breakdown product(s) or common mechanism(s) of action]
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
[Provide here, if relevant, additional information to that included in the Test material section of the source and target records]
3. ANALOGUE APPROACH JUSTIFICATION
[Summarise here based on available experimental data how these results verify that the read-across is justified]
4. DATA MATRIX
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: read across approach
- Adequacy of study:
- supporting study
- Reliability:
- other: data matrix read across approach
- Rationale for reliability incl. deficiencies:
- other: data matrix read across approach, target chemical SMBT, source chemical MBT
- Principles of method if other than guideline:
- other: data matrix read across approach
SMBT is a sodium salt of MBT (mass content SMBT: MBT 88%, sodium: 12%). SMBT is a strong base (pH 10, as discussed in chapter 1.3) and is classified as corrosive (R34/category 1C). The corrosive character of SMBT is the predominant local effect and determines the local DNEL. According to ECHA Guidance Document Part E: Risk Characterisation, substances with R-phrases R34 (causes burs), R41 (risk of serious damage to the eyes), which relate to corrosive or severe irritant effects to the eye or irritant effects to the eyes are allocated to the moderate hazard category.
Read across approach (systemic effects)
There are no toxicokinetic data, no valid repeated dose study data and reproduction toxicity data available for SMBT. A read-across approach with systemic toxicity data from MBT (benzothiazole-2 -thiol) was performed. In addition, the second component the sodium ion Na+ is briefly discussed.
The available systemic mammalian toxicity data from SMBT were compared with data from MBT (see table data matrix). Similarities in mammalian systemic toxicity were noted in SMBT and MBT treated animals. The oral and dermal toxicity of SMBT and MBT is very low, indicated by oral LD50 values > 2000 mg/kg bw and dermal LD50 values >7940 mg/kg bw. No mutagenic potential or even a weak response was indicated for SMBT and MBt in bacteria.
Data Matrix, analogue approach
Target Chemical (SMBT) | Source Chemical (MBT) | |
CAS # | 2492-26-4 | 149-30-4 |
Chemical Name | sodium benzothiazol-2-yl sulphide | benzothiazole-2-thiol |
Structure | ||
Physico-Chemical Data | ||
Physical state at 20°C and 101.3 kPa | liquid (aqueous solution) | solid (crystalline) |
Appearance | Colour: yellowish-brown | colour: yellow |
Molecular weight range | 189.2331 g/mol | 167.2513 g/mol |
Relative density | 1.26 kg/l (20°C) was reported by Lanxess 50% solution and 1.14 kg/l (20°C) for 30% solution | 1.42 g/cm³ at 20°C. (Lide 2002) |
Water solubility | liquid (aqueous solution) | 118 mg/l at 25°C and pH 7. (Monsanto 1980) |
Mammalian Toxicity | ||
Dermal irritation/corrosion | corrosive | not irritating rabbit (Monsanto Co. 1975) |
Eye irritation | corrosive | not irritating rabbit (New Zealand White) (Monsanto Co. 1975) |
Dermal sensitization | corrosive | moderate skin sensitizing Guinea pig maximisation test (Bayer AG 1999) |
Mutagenicity (bacteria) | Ames assay: negative (Monsanto Co. 1976, Goodyear 1979)Ames assay: weak positive (NTP 1984) | Ames assay: negative (CMA 1984) |
Mutagenicity in vivo assays | no data | Genotoxicity: negative micronucleus assay (CMA 1984) |
Acute toxicity (oral) | LD50: 2100 mg/kg bw (Bayer AG 1978) | LD50: 3800 mg/kg bw rat (Monsanto Co.1975) |
Acute toxicity (inhalation) | no valid data available | no data available |
Acute toxicity (dermal) | LD50:> 7940 mg/kg bw (Monsanto Co. 1974) | LD50: > 7940 mg/kg bw (Monsanto Co.1975) |
Sodium
Sodium is the quantitative main cation of the extracellular room. In combination with other electrolytes as chloride and potassium, the sodium ion is involved in several essential functions in the human body. The main function is the maintenance of the extracellular volumes, the regulation of the osmotic pressure, the regulation of the acid-base homeostasis, production of gastric acid, activation of enzymes and the trans-membrane potential (e.g. transmitting signals in neurons and muscle cells). The recommended daily intake is in the range of 575 to 3500 mg Na+/day (SCF 2003).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Read-across from supporting substance (structural analogue or surrogate). Additional, the test substance is classified as corrosive to skin; according to REACH regulation Annex VII, chapter 8.3. skin sensitization, column 2, in vivo testing does not need to be conducted.
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Details on test material:
- 2-mercaptobenzothiazole, batch no. 01631-077 (supplied by Aldrich Chemie)
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: HSD Poc:DH strain
- Sex:
- female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- physiological saline
- Concentration / amount:
- intradermal induction: 5 % (= 20 mg test item/animal) topical induction: 25 % (= 125 mg test item/animal), challenge: 12 % (= 60 mg test item/animal)
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- physiological saline
- Concentration / amount:
- intradermal induction: 5 % (= 20 mg test item/animal) topical induction: 25 % (= 125 mg test item/animal), challenge: 12 % (= 60 mg test item/animal)
- No. of animals per dose:
- treatment group: 10, neagitve control: 5
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 12 %
- No. with + reactions:
- 7
- Total no. in group:
- 10
- Clinical observations:
- Appearance and behavior of the test item group were not different from control group
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: 12 %. No with. + reactions: 7.0. Total no. in groups: 10.0. Clinical observations: Appearance and behavior of the test item group were not different from control group.
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- 12 %
- No. with + reactions:
- 6
- Total no. in group:
- 10
- Clinical observations:
- Appearance and behavior of the test item group were not different from control group
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 2nd reading. . Hours after challenge: 72.0. Group: test group. Dose level: 12 %. No with. + reactions: 6.0. Total no. in groups: 10.0. Clinical observations: Appearance and behavior of the test item group were not different from control group.
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0
- No. with + reactions:
- 1
- Total no. in group:
- 5
- Clinical observations:
- no effects
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 0. No with. + reactions: 1.0. Total no. in groups: 5.0. Clinical observations: no effects.
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- negative control
- Dose level:
- 0
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 72.0. Group: negative control. Dose level: 0. No with. + reactions: 0.0. Total no. in groups: 5.0.
Any other information on results incl. tables
At the end of the study , the mean body weight of the treatment group animals was slightly higher than that of the control group animals.
The total number of animals with skin reactions was 70 % in the test substance group and 20 % in the control group.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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