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EC number: 601-017-1 | CAS number: 110964-79-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.78 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
-
Repeated
dose toxicity:
The dose descriptor starting point was the NOAEL of 50.6 mg/kg bw from a 90d feeding study. The corrected starting point (inhalatory NOAEC) was 44.6 mg/m3. Applying an overall assessment factor of 25 results in a DNEL of 1.78 mg/m3 for an 8h working day. -
Sensitisation
(skin):
Step 1, qualitative approach:
According to Chapter R.8, Table R.8-23 and based on the results of a LLNA skin sensitising potency of 4-Methylsulfonyl-2-nitrobenzoic acid is categorised as “strong”, because EC3(%) is > 0.2 and < 2.0. According to section E.3.4 for extreme and strong sensitizers RMMs, OCs, and PPE have to be considered as listed under “High Hazard” in Table E.3-1.
Step 2, DNEL setting:
For the judgement of the remaining risks after RMMs and OCs implementation a DNEL was derived as follows:
The highest 4-Methylsulfonyl-2-nitrobenzoic acid concentration tested, that didn’t induce a SI above 3, was found to be 1%. Conversion into µg/cm2results in a value of:
1% x 250 µg/cm2/ % = 250 µg/cm2
that can be considered as the NOAEL for induction. -
Effect
on fertility
The composition of 4-Methylsulfonyl-2-nitrobenzoic acid is as follows:
80% 4-Methylsulfonyl-2-nitrobenzoic acid, 17% water, 2%NMST (1-methyl-4-(methylsulfonyl)-2-nitrobenzene, CAS#1671-49-4). NMST is classified as Repr. Cat. 3; R62 - Xn; R22 - R43 - R52-53 (1st ATP to Regulation (EC) No 1272/2008). Based on a study according to OECD 415 the NOAEL for the reproductive toxicity (male fertility) of NMST has been set at 15 mg/kg bw.. This value is equivalent to a 4-Methylsulfonyl-2-nitrobenzoic acid dose of 750 mg/kg bw.. Since this value is clearly above the NOAEL of 50.6 mg/kg bw for 90d repeated dose toxicity of 4-Methylsulfonyl-2-nitrobenzoic acid, derivation of an additional DNEL for reproductive toxicity is dispensable (even then, when considering an additional assessmenet factor of 3 for the dose response curve motivated by the severity of fertility effects seen at LOAEL (100 mg/kg bw) in the reproductive toxicity study).
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
4-Methylsulfonyl-2-nitrobenzoic acid is an intermediate handled under SCC. Therefore an exposure of the general population is excluded. Consequently there is no need for DNEL derivation for the general population.
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