Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
not specified
Remarks:
summary of toxicological data
Adequacy of study:
other information
Reliability:
other: summary of toxicological data
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2006
Report date:
2006

Materials and methods

Type of study / information:
Summary of toxicological data of IPM
Test guideline
Qualifier:
no guideline required
GLP compliance:
no

Test material

Constituent 1
Test material form:
liquid

Results and discussion

Any other information on results incl. tables

IPM will be used in a catalyst system during the polymerisation process of polypropylene resin that can be used to manufacture food contact articles.

It was negative in an AMES study with and without metabolic activation.

It is considered Cramer class 1.

SAR modeling predicted negative genetic toxicity potential.

A search for FDA Genetic Toxicity Database for compounds with similar structure indicated that even more complex esters were negative in genetic toxicity tests.

It was not carcinogenic in two tumor assays.

It is thought to readily hydrolyse in vivo into innocuous compounds.

Lack of systemic bioavaibility.

Lack of mammalian bioaccumulation.

Applicant's summary and conclusion

Conclusions:
Summary of genetic toxicity potential of IPM: No genetic toxicity potential found yet. Further studies not needed.