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EC number: 603-689-1 | CAS number: 132961-05-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-09-24 to 1991-09-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
- EC Number:
- 603-689-1
- Cas Number:
- 132961-05-8
- Molecular formula:
- C23H28F2N4O2
- IUPAC Name:
- 3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: T 1624
- Analytical purity: 99.8% (w/w) based on base titration, 101.6% (w/w) based on acid titration
- Lot/batch No.: BEA011
- Storage condition of test material: at room temperature in closed containers
Test animals
- Species:
- rabbit
- Strain:
- other: Cunistar-MDL albino rabbits
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: established stock-farm of Buyens, Lichtaart, Belgium
- Age at study initiation: adult
- Weight at study initiation: 2.290 - 2.600 kg
- Housing: Rabbits were housed in an air-conditioned room individually in numbered metallic cages. The cages consisted of stainless steel walls and a wire mesh bottom and front door. The cages were suspended in racks above stainless steel drains with scrapers and sink holes for the collection of faeces and urine.
- Diet: The food consisted of Huybrechts pelleted rabbit food administered in self-raising hoppers and fed ad libitum throughout the study.
- Water: free and continuous access to fresh tap-water via automatic drinking nipples, ad libitum
- Acclimation period: one week
ENVIRONMENTAL CONDITIONS: no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- other: adjacent areas of the untreated shaved skin serving as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 grams per rabbit
- Concentration (if solution): 50 mg/100 mg
VEHICLE
- Amount(s) applied: no data
- Concentration: no data
- Lot/batch no.: no data
- Purity: no data - Duration of treatment / exposure:
- four hours
- Observation period:
- 72 hours (3 days)
- Number of animals:
- three male rabbits
- Details on study design:
- TEST SITE
- Area of exposure: about 6 square cm on shaved area of the back
- % coverage: no data
- Type of wrap if used: occlusive patch
REMOVAL OF TEST SUBSTANCE
- Washing: Residual test substance was removed with water, without altering the existing response or integrity of epidermis
- Time after start of exposure: four hours
SCORING SYSTEM:
Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: A score of 0 was observed for all animals and all timepoints.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: A score of 0 was observed for all animals and all timepoints.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: A score of 0 was observed for all animals and all timepoints.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: A score of 0 was observed for all animals and all timepoints.
- Irritant / corrosive response data:
- No irritation was observed in any of the three animals. The erythema and oedema scores at 1, 24, 48, and 72 hours were 0 in all animals.
- Other effects:
- Body weight remained normal in all rabbits during the 3-day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- T 1624, when given to Cunistar-MDL albino rabbits at a single dose of 0.5 g/rabbit by dermal application, produced no dermal irritation. Therefore, the test item should be considered not to be classified.
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