Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 280-489-7 | CAS number: 83567-04-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From July 12, 1982 to July 26, 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- Abraded and intact dorsal skin (previously clipped) of six New-Zealand white rabbits was exposed to 500 mg test substance for 24 h under occlusive conditions. At the end of the exposure period, the treated skin area was cleaned and irritation/corrosion was assessed at 24, 48 and 72 h and at 1 and 2 weeks according to Draize scoring system.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Trisodium 7-[[4-chloro-6-[ethyl[3-[[2-(sulphonatooxy)ethyl]sulphonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(4-methoxy-2-sulphonatophenyl)azo]naphthalene-2-sulphonate
- EC Number:
- 280-489-7
- EC Name:
- Trisodium 7-[[4-chloro-6-[ethyl[3-[[2-(sulphonatooxy)ethyl]sulphonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(4-methoxy-2-sulphonatophenyl)azo]naphthalene-2-sulphonate
- Cas Number:
- 83567-04-8
- Molecular formula:
- C30H28ClN7O14S4.3Na C30H25ClN7Na3O14S4
- IUPAC Name:
- trisodium 7-[[4-chloro-6-[ethyl[3-[[2-(sulphonatooxy)ethyl]sulphonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(4-methoxy-2-sulphonatophenyl)azo]naphthalene-2-sulphonate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Origin: Nihon Dobutsu Co., Osaka
Body weight: 2.28 - 3.17 kg
Temperature and relative humidity: 24+/-2°C and 60+/-10%, respectively
Lighting time: 12 h daily
Food: CG-3 type (100 g/day)
Water: tap water, ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded or intact
- Remarks:
- previously clipped
- Vehicle:
- physiological saline
- Amount / concentration applied:
- 500 mg of the test substance (slightly moistened with physiological saline) on 1 x 1 inch lint patch
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 14 d
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 4x (2.5 x 2.5 cm²) 2 shaved and 2 abraded sites per anmal
- % coverage:
- Type of wrap if used: Blenderm® surgical tape, 3M Co., Saint Paul, U.S.A.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): at the end of exposure period, the patches were removed from the skin and the treated area was wiped to remove the remaining test material.
- Time after start of exposure:24 h
OBSERVATION TIME POINTS
24, 48 and 72 hrs and 1 and 2 weeks after application
SCORING SYSTEM: Skin reactions of erythema and edema were scored 24, 48 and 72 h and 1 and 2 weeks after application according to the Draize scoring system.
- Method of calculation: Primary irritation score= Sum of (Total scores of erythema and edema at 24 and 72 hrs in 2 intact and 2 abraded skins / 8) for all 6 rabbits / 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- shaved skin
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- shaved skin
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- shaved and abraded skin
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 24 and 72 h
- Score:
- 0.17
- Max. score:
- 8
- Reversibility:
- fully reversible within: 14 d
- Irritant / corrosive response data:
- The the test material produced very slight erythema and slight edema at 24 hrs after application in one abraded skin patch, any other skin irritant reactions were not observed. The erythema gradually developed into eschar at 3 days, and disappeared within 10 days. The edema have gradually disappeared within 14 days. The primary irritation score was 0.17.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the study conditions, the substance was not considered to be irritating to skin.
- Executive summary:
A study was conducted to determine the in vivo skin irritation potential of the substance according to an internal method of the laboratory. Clipped abraded and intact dorsal skin (ca. 1 x 1 inch) of six New-Zealand white rabbits was exposed to 500 mg of the test substance (slightly moistened with physiological saline) for 24 h under occlusive conditions. At the end of the exposure period, the treated skin area was carefully cleaned. Skin irritation/corrosion was assessed at 24, 48 and 72 h as well as at 1 and 2 weeks after bandage removal according to the Draize scoring system. The test substance produced some grade of erythema and eschar and very slight edema at 24 h after application only in one abraded skin. These changes disappeared within 14 d after application. Under the study conditions, the substance was not considered to be irritating to skin (Hosokawa, 1982).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.