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EC number: 420-150-4 | CAS number: 80498-15-3 SP 807
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Laccase is neither a skin or an eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From June 28, 1996 to October 07, 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bred by Novo Nordisk A/S, Denmark
- Weight at study initiation: between 2.6-2.9 kg
- Age at study initiation: 21 wk old adults
- Housing: Individually, in animal room with control of temperature (17-23°C) and humidity (30-70%RH)
- Diet : Standard diet 130 g daily
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: 6 days
- Photoperiod (hrs dark / hrs light): 12 hrs/12hrs
IN-LIFE DATES: From: 1996-07-09 To: 1996-07-15 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- physiological saline
- Remarks:
- 500 mg of freeze-dried test batch PPX 5660, ca. 450 mg Total Organic Solids (TOS) was moistened with 0.9% w/v NaCl.
- Controls:
- not required
- Amount / concentration applied:
- 470 mg TOS (total organic solid)
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 6 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: the patch was covered with Hansapor sterile wound dressing (Beiersdorf) and an elastic tubular support bandage was further applied to prevent the animals from damaging the patch.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with water
- Time after start of exposure: 4 hrs
SCORING SYSTEM: According to the standard scoring system of OECD test guideline 404. - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hrs
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 6 days
- Remarks on result:
- other: No reading at day 4 and 5, so reactions might have cleared earlier.
- Irritation parameter:
- erythema score
- Max. score:
- 1
- Remarks on result:
- other: Max. duration: 6d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0 d; Max. value at end of observation period: 0 (related to all animals)
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 6 days
- Other effects:
- No clinical reaction to treatment was observed throughout the study.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, laccase can be classified as non-irritant to the skin.
- Executive summary:
In accordance with OECD guideline 404, a primary skin irritation test in rabbits was performed with Laccase, batch PPX 5660.The present batch was a light brown powder, a highly concentrated freeze-dried version of the liquid batch PPX 5326 used in the previous skin irritation study. The study was conducted in accordance with GLP.
On the intact skin of the clipped back of each the 3 rabbits, 0.5 g of the batch moistened with saline was applied under a patch of gauze (2.5 x 2.5 cm). A semiocclusive bandage was utilised and the adjacent areas of untreated skin served as control.
After 4 hours exposure the patches and the remaining test substance were removed by gentle washing, and the skin reaction, erythema-, eschar- and edema formation was evaluated ½-1, 24, 48 and 72 hours and also 6 days after. Slight reversible erythema reactions were noted in 2 rabbits, one of them up to day 3. Max score was 1. The reaction had cleared at the reading on day 6, however no reading was performed at day 4 and 5, so the reaction might have cleared earlier. No edema was seen in any of the animals.
In conclusion, laccase can be classified as non-irritant to the skin.
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- From January 22, 1996 to March 13, 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bred by Novo Nordisk A/S, Denmark
- Weight at study initiation: between 2.3-2.4 kg
- Age at study initiation: 14 wk old adults
- Housing: Individually, in animal room with control of temperature (17-24°C) and humidity (30-70%RH)
- Diet : Standard diet 130 g daily
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: 6 days
- Photoperiod (hrs dark / hrs light): 12 hrs/12hrs
IN-LIFE DATES: From: 1996-01-30 To: 1996-02-02 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- Test batch used as is: 0.5 mL of density 1.024 g/ml and 6.6% Total Organic Solids (TOS), corresponding to 34 mg TOS.
- Controls:
- not required
- Amount / concentration applied:
- - Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): undiluted, i.e. 34 mg Total Organic Solids (TOS)/ 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: the patch was covered with 3M Micropore Surgical tape 1530-3 and an elastic tubular support bandage was further applied to prevent the animals from damaging the patch.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with water
- Time after start of exposure: 4 hrs
SCORING SYSTEM: According to the standard scoring system of OECD test guideline 404. - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0 d; Max. value at end of observation period: 0 (related to all animals)
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0 d: Max. value at end of observation period: 0 (related to all animals)
- Irritant / corrosive response data:
- No erythema, eschar formation or oedema was observed at the test sites at any of the three rabbits, neither at termination of exposure or at the examinations 1 hour, 24, 48 or 72 hours after termination of exposure.
- Other effects:
- No systemic effects or other effects were observed throughout the study.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, laccase can be classified as non-irritant to the skin.
- Executive summary:
In accordance with OECD guideline 404, a primary skin irritation test in rabbits was performed with laccase, batch PPX 5326.The study was conducted in accordance with GLP.
On the intact skin of the clipped back of each the 3 rabbits, 0.5 mL of the undiluted batch was applied under a patch of gauze (2.5 x 2.5 cm). A semiocclusive bandage was utilised and the adjacent areas of untreated skin served as control.
After 4 hours exposure the patches and the remaining test substance were removed by gentle washing, and the skin reaction, erythema-, eschar- and edema formation was evaluated after ½-1, 24, 48 and 72 hours. None of the rabbits exhibited any dermal reactions at the test side.
In conclusion, laccase can be classified as non-irritant to the skin according to the criteria of EU.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From June 28, 1996 to October 07, 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1987.
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Bred by Novo Nordisk A/S, Denmark
- Weight at study initiation: between 2.7-2.8 kg
- Age at study initiation: 21 wk old adults
- Housing: Individually, in animal room with control of temperature (17-23°C) and humidity (30-70%RH)
- Diet : Standard diet 130 g daily
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: 5 days
- Photoperiod (hrs dark / hrs light): 12 hrs/12hrs
IN-LIFE DATES: From: 1996-07-08 To: 1996-07-15 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Test batch used as is: 0.1 g of 91.7 % TOS (total organic solid), corresponding to 92 mg TOS.
- Duration of treatment / exposure:
- The test material was applied to the conjunctival sac, no further action done, i.e. no washing.
- Observation period (in vivo):
- The reactions were judged 1, 24, 48 and 72 hours after instillation of the test material.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: No
SCORING SYSTEM: The ocular reactions were recorded at 1, 24, 48 and 72 hours after instillation according to the guideline.
TOOL USED TO ASSESS SCORE: Ophtalmoscope. Flourescein was not used as there were no corneal reactions. - Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- Only slight reactions on conjunctiva were observed after instillation of the freeze-dried powder, batch PPX 5660, with no reactions on cornea or iris. The conjunctival reactions were fully reversible within 48 hours after instillation.
- Other effects:
- None
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, laccase can be classified as a ‘non irritant’ to the rabbit eye.
- Executive summary:
In accordance with the OECD guideline 405, a test for eye irritation in rabbits was performed with Laccase, batch PPX 5660.
The eyes of each animal were checked for defects or irritation before instillation and only animals without defects were used.
0.1 g of the freeze-dried Laccase, batch PPX 5660 was placed in the conjunctival sac of the left eye by pulling the lower eyelid away from the eyeball. The lids were gently held together for about one second after instillation. The untreated eye served as control. The ocular reactions were recorded at 1, 24, 48 and 72 hours after instillation according to the specified guideline. Only slight reactions on conjunctiva were observed after instillation of the freeze-dried powder, batch PPX 5660, with no reactions on cornea or iris. The conjunctival reactions were fully reversible within 48 hours after instillation.
In conclusion, laccase can be classified as a ‘non irritant’ to the rabbit eye.
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- From January 22, 1996 to March 04, 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1987.
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Bred by Novo Nordisk A/S, Denmark
- Weight at study initiation: between 2.4-2.5 kg
- Age at study initiation: 14 wk old adults
- Housing: Individually, in animal room with control of temperature (17-23°C) and humidity (30-70%RH)
- Diet : Standard diet 130 g daily
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: 5 days
- Photoperiod (hrs dark / hrs light): 12 hrs/12hrs
IN-LIFE DATES: From: 1996-01-29 To: 1996-02-02 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Test batch used as is: 0.1 ml of density 1.024 g/ml and 6.6% TOS (total organic solid), corresponding to 6.8 mg TOS.
- Duration of treatment / exposure:
- The test material was applied to the conjunctivel sac, no further action done, i.e. no washing.
- Observation period (in vivo):
- The reactions were judged 1, 24, 48 and 72 hours after instillation of the test material.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: No
SCORING SYSTEM: The ocular reactions were recorded at 1, 24, 48 and 72 hours after instillation according to the guideline.
TOOL USED TO ASSESS SCORE: Ophtalmoscope. Flourescein was not used as there were no corneal reactions. - Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #1
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #2
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #3
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- No reactions on cornea, iris or conjunctiva were elicited after instillation of the liquid laccase, batch PPX 5326.
- Other effects:
- None
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, laccase can be classified as a ‘non irritant’ to the rabbit eye.
- Executive summary:
In accordance with the OECD guideline 405, a test for eye irritation in rabbits was performed with Laccase, batch PPX 5326.
The eyes of each animal were checked for defects or irritation before instillation and only animals without defects were used.
0.1 mL of Laccase, batch PPX 5326 was placed in the conjunctival sac of the left eye by pulling the lower eyelid away from the eyeball. The lids were gently held together for about one second after instillation. The untreated eye served as control. The ocular reactions were recorded at 1, 24, 48 and 72 hours after instillation according to the specified guideline. No reactions on cornea, iris or conjunctiva were elicited after instillation of the liquid batch, PPX 5326.
In conclusion laccase can be classified as a ‘non irritant’ to the rabbit eye.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The skin and eye irritation potential of laccase has been tested according to OECD guidelines, and in compliance with GLP. Two studies have been performed on each endpoint, one with the liquid laccase batch and one with the freeze-dried, highly concentrated version of the batch. The only reactions seen were slight redness of conjunctiva in 2 rabbits (max score 1) and slight chemosis in one rabbit (max score 1) in the eye irritation study on the freeze-dried laccase (all totally cleared at 48h), all other readings in both studies were score 0. In the skin irritation studies, slight reversible erythema reactions were noted in 2 rabbits, one of them up to day 3 in the study on the freeze-dried laccase. Max score was 1. The reaction had cleared at the reading on day 6, however, no reading was performed at day 4 and 5, so the reaction might have cleared earlier. All other readings in both skin irritation studies were score 0.
The conclusion was that laccase did not exert any skin and eye irritation.
Justification for selection of skin irritation / corrosion
endpoint:
Key study selected as most relevant study of highest concern.
Justification for selection of eye irritation endpoint:
Key study selected as most relevant study of highest concern.
Justification for classification or non-classification
The skin and eye irritation potential of laccase has been tested according to OECD guidelines, and in compliance with GLP. The conclusion was that laccase did not exert any skin and eye irritation.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.