Registration Dossier
Registration Dossier
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EC number: 295-762-6 | CAS number: 92128-65-9
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Adequacy of study:
- other information
Data source
Reference
- Title:
- No information
- Author:
- Irons R.D. & Moore B.J. Res. Commun. Chem. Path. Pharmac.|27, 147 155, 1980.
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: other TS
Laboratory reagent grade benzene tested.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
Administration / exposure
- Route of administration:
- subcutaneous
- Duration of treatment / exposure:
- 10 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.25, 0.5 ml/kg bw/day (converts to 219.5, 439 mg/kg bw/day); 8 or 9 rabbits/dose
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Post-exposure period: 30 days
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- < 219.5 mg/kg bw/day
- Sex:
- female
- Dose descriptor:
- LOAEL
- Effect level:
- 219.5 mg/kg bw/day
- Sex:
- female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
A dose- and time-dependent decrease in circulating lymphocytes which partially recovered 30 days after treatment, was noted. Circulating monocytes were significantly decreased in the top-dosed animals.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
