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Diss Factsheets
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EC number: 801-607-0 | CAS number: 302962-49-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
Eye contact
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
Skin contact
If ON SKIN: Wash with plenty of soap and water. If skin irritation occurs, get medical advice/attention.
Inhalation
Move to fresh air. Oxygen or artificial respiration if needed. If exposed or concerned: Get medical attention/advice.
Ingestion
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Never give anything by mouth to an unconscious person.
Notes to Physician
Medical conditions aggravated include: liver disorders, vascular disorders, bleeding, oedema. This product has been reported to interact with the following medications: drugs that inhibit cytochrome P-450, cardiovascular drugs, anticoagulants. Material not fully tested.
Medical Surveillance
The need for a pre-placement, follow-up physical examination and history for employees with potential exposure to this compound is to be evaluated by a physician that is thoroughly knowledgeable about both the toxicity of this compound and the extent of work place exposure. Baseline testing would include: a complete blood count with differential, a blood test for liver function. Based on opportunity for exposure and duration of exposure a periodic follow-up examination may be considered. This exam should be overseen by a physician thoroughly knowledgeable about both the toxicity of this compound and the extent of work place exposure. It is recommended that the content be similar to the pre-placement exam.
Employees who are pregnant, are breast-feeding, or who are concerned with other reproductive issues should be encouraged to consult with the occupational health physician monitoring worker's health.
Fire-fighting measures
Flammable Properties
Flammable solid
Extinguishing Media
Suitable extinguishing media: Dry chemical, Water spray, Foam
Unsuitable extinguishing media: Do NOT use water jet.
Protection of Firefighters
Specific hazards: Not available
Protective equipment: Use personal protective equipment. In the event of fire, wear self-contained breathing apparatus.
Hazardous Combustion Products: carbon oxides (COx), nitrogen oxides (NOx), sulphur compounds
Other information
Decontaminate protective clothing and equipment before reuse.
Accidental release measures
Personal precautions
Use personal protective equipment. Examples include tightly fitting safety goggles, disposable lab coat of low permeability with cuffs, double gloves and shoe covers. Wear respiratory protection. Depending on the nature of the spill (quantity and extent of spill) additional protective clothing and equipment such as a self-contained breathing apparatus may be needed.
Environmental precautions
Prevent release to drains and waterways. Prevent release to the environment.
Containment Methods
Wet down any dust to prevent generation of aerosols, if appropriate. Cover with suitable material.
Cleanup Methods
Spill prevention procedures and a spill response procedure should be implemented. Contain and collect spillage and place in container for disposal according to local regulations. Clean spill area with a deactivating solution (if available) followed by detergent and water after spill pick-up. Handle waste materials, including gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for chemically and pharmacologically similar materials.
Handling and storage
Handling Precautions
Highly potent material. Avoid exposure - obtain special instructions before use. Avoid formation of dust and aerosols. Keep away from heat and sources of ignition. Prevent release to drains and waterways.
Container Requirements
Store in sturdy containers appropriate to maintain the integrity of this material for its intended use.
Storage Conditions
Store at room temperature. Protect against light. Keep away from heat, sparks and flames. Store locked up.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- UN2926
Shippingopen allclose all
SpecialProvisionsopen allclose all
Shippingopen allclose all
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- UN2926
Shipping information
- Proper shipping name and description:
- FLAMMABLE SOLID, TOXIC, ORGANIC, N.O.S. (n-butanol derivative)
- Labels:
- 4.1, 6.1
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- UN2926
Shipping information
- Proper shipping name and description:
- FLAMMABLE SOLID, TOXIC, ORGANIC, N.O.S. (n-butanol derivative)
- Labels:
- 4.1, 6.1
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Recommended Industrial Hygiene Monitoring Methods
A specific exposure sampling method is not available. Contact the Bristol-Myers Squibb AIHA accredited Industrial Hygiene Laboratory at (USA) 732-227-6338.
General - The health hazard risk of handling this material is dependent on many factors, including physical form, % API in material being handled, duration and frequency of process task, and effectiveness of controls. If it is necessary to handle this compound outside of engineering controls, an exposure risk assessment should be conducted and procedures documented by a qualified EHS professional.
Engineering Controls and Ventilation
Use process enclosures, containment technology, or other engineering controls to keep airborne levels below recommended exposure limit. When handling quantities up to 3 milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air changes per hour) is appropriate. When handling quantities up to 1 kilogram, work in either a standard laboratory (<500 g) or designated laboratory (500 g to <1 kg) using a fume hood, biological safety cabinet(Class II, Type A2 with thimble connection, B1, or B2)or approved vented enclosure. HEPA filtered exhaust preferred for fume hoods containing particularly "dusty" operations. Quantities exceeding 1 kilogram should be handled in a designated laboratory or containment facility using appropriate containment technology. A laminar flow/powder containment booth or appropriate isolation technology should be considered for handling more than 1 kilogram of active compound. HEPA filtered exhaust preferred. For manufacturing and pilot plant operations, barrier/containment technology and direct coupling (totally enclosed processes that create a barrier between the equipment and the room) with use of double or split butterfly valves, hybrid unidirectional airflow/local exhaust ventilation solutions (e.g. powder containment booth) should be used. Glove bags, isolator/glove box systems are optional. HEPA filtration of exhaust from dry product handling areas is required.
Respiratory protection
Use and selection of respiratory protection is based upon engineering controls in use and potential for aerosol generation. When engineering controls are not sufficient control exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate (HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters (EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tight-fitting, full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied air respirator (EN 139) operated in a pressure demand or other positive pressure mode when exposures are 100-1000 times the exposure control guideline.
Eye protection
Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety goggles (EN 166) may be required if splash potential exists or if corrosive materials are present. Note: Choice of eye protection may be influenced by the type of respirator which is selected.
Hand protection
Wear gloves at all times when handling containers, including when unpacking, inspecting or transporting within a facility. Impervious gloves are recommended. (EN 420, EN 374). Double gloving for all manufacturing personnel potentially in direct contact with the compound should be considered. If material is handled in solution, the solvent should also be considered when selecting protective clothing material.
Skin and body protection
Wear a laboratory coat (EN 340) when handling quantities up to 500 grams. For quantities up to 1 kilogram, wear disposable laboratory coat (EN 340) or coverall of low permeability (EN 1149-1) . For quantities over 1 kilogram and manufacturing operations, wear disposable coverall of low permeability (EN 1149-1) and disposable shoe covers.
Hygiene
Wash hands and face before breaks and immediately after handling the product.
Environmental exposure controls
Prevent release to drains and waterways.
Stability and reactivity
Chemical Stability: Stable under normal conditions.
Conditions to avoid: Not available
Materials to avoid: Not available
Hazardous decomposition products: Hazardous decomposition products formed under fire conditions.: carbon oxides (COx), nitrogen oxides (NOx), sulphur compounds.
Hazardous reactions: None known.
Sensitivity to static discharge/Dust exp.: Although material has not been specifically tested, fine dust suspended in air in sufficient concentration and in the presence of an ignition source may pose a potential explosion hazard. Provide appropriate bonding and grounding protection to control static charge. Powder handling equipment such as dust collectors, dryers, and mills may require additional protective measures (e.g. explosion venting, inerting, etc.).
Disposal considerations
Advice On Disposal And Packaging: Disposal should be in accordance with applicable regional, national and local laws and regulations. Local regulations may be more stringent than regional or national requirements. This information presented only applies to the material as supplied.
Other information: Disposal by incineration is recommended.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.