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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Final Report on the Safety Assessment of Oleic Acid, Laurie Acid, Palmitic Acid, Myristic Acid, and Stearic Acid
Author:
Cosmetic Ingredient Review (CIR) Panel
Year:
1987
Bibliographic source:
JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY Volume 6, Number 3, 1987.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
A single insult occlusive patch test (SIOPT) was conducted to assess the skin irritation potential of test chemical Palmitic acid (CAS No: 57-10-3) in six albino rabbits.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Palmitic acid
EC Number:
200-312-9
EC Name:
Palmitic acid
Cas Number:
57-10-3
Molecular formula:
C16H32O2
IUPAC Name:
Hexadecanoic acid
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report): Palmitic acid
- Molecular formula: C16H32O2
- Molecular weight: 256.4268 g/mol
- Substance type: organic
- Physical state: solid
- Smiles: C(CCCCCCCCCC)CCCCC(=O)O
- InChI: 1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
Specific details on test material used for the study:
- Name of test material (as cited in study report): Palmitic acid
- Molecular formula: C16H32O2
- Molecular weight: 256.4268 g/mol
- Substance type: organic
- Physical state: solid
- Smiles: C(CCCCCCCCCC)CCCCC(=O)O
- InChI: 1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

Test animals

Species:
rabbit
Strain:
other: Albino
Details on test animals or test system and environmental conditions:
No Data Available

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact and abraded sites
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
0.05ml
Duration of treatment / exposure:
No Data Available
Observation period:
No Data Available
Number of animals:
6
Details on study design:
No Data Available

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No known signs of skin irritation were observed.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material Palmitic acid (CAS No: 57-10-3) was considered to be not irritating to the skin of albino rabbits.
Executive summary:

A single insult occlusive patch test (SIOPT) was conducted to assess the skin irritation potential of test chemical Palmitic acid (CAS No: 57-10-3) in six albino rabbits.

 

In this study, the 0.05ml of chemical was applied to the intact and abraded skin of each rabbits and later observed for skin lesions.

 

No known signs of irritation were observed in treated aanimals. Hence the test chemical Palmitic acid (CAS No: 57-10-3)was considered to be not irritating to the skin ofalbinorabbits.