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Diss Factsheets
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EC number: 222-377-2 | CAS number: 3453-33-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from NTRL report
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- FINAL REPORT OF SEVERAL STUDIES ON VANILLIN WITH COVER LETTER DATED 112191
- Author:
- NTRL (National Technical Reports Library)
- Year:
- 1 991
- Bibliographic source:
- NTRL (National Technical Reports Library); OTS05343EA; 22 NOVEMBER 1991
- Reference Type:
- secondary source
- Title:
- SIDS INITIAL ASSESSMENT REPORT- Vanillin
- Author:
- OECD SIDS
- Year:
- 1 996
- Bibliographic source:
- SIDS INITIAL ASSESSMENT REPORT- Vanillin; OECD SIDS; 28/10/1996.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An eye irritation test of Vanillin (CAS No: 121-33-5) was performed in six New Zealand White rabbits to assess its eye irritation potential.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Vanillin
- EC Number:
- 204-465-2
- EC Name:
- Vanillin
- Cas Number:
- 121-33-5
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1-butoxypropan-2-ol
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Vanillin
- Molecular formula: C8H8O3
- Molecular weight: 152.1482 g/mol
- Substance type: organic
- Physical state: Solid
-Smiles: c1(cc(ccc1O)C=O)OC
-InChI: 1S/C8H8O3/c1-11-8-4-6(5-9)2-3-7(8)10/h2-5,10H,1H3
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Vanillin
- Molecular formula: C8H8O3
- Molecular weight: 152.1482 g/mol
- Substance type: organic
- Physical state: Solid
-Smiles: c1(cc(ccc1O)C=O)OC
-InChI: 1S/C8H8O3/c1-11-8-4-6(5-9)2-3-7(8)10/h2-5,10H,1H3
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand Black
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500mg (0.1ml)
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- SCORING SYSTEM: Federal Hazardous Substances Act (FHSA)
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 18.8
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Mild irritating effects were observed.
Any other information on results incl. tables
EYE IRRITATION SCORES |
||||||||||||||||||
Hours |
1 |
24 |
48 |
72 |
120 |
168 |
||||||||||||
Structure |
Cr |
Ir |
Con |
Cr |
Ir |
Con |
Cr |
Ir |
Con |
Cr |
Ir |
Con |
Cr |
Ir |
Con |
Cr |
Ir |
Con |
Animal no. |
||||||||||||||||||
1 |
0 |
0 |
10 |
10 |
5 |
14 |
5 |
5 |
12 |
0 |
0 |
8 |
0 |
0 |
2 |
0 |
0 |
0 |
2 |
0 |
0 |
10 |
5 |
0 |
14 |
5 |
0 |
12 |
0 |
0 |
8 |
0 |
0 |
2 |
0 |
0 |
0 |
3 |
0 |
0 |
14 |
20 |
5 |
16 |
20 |
5 |
12 |
10 |
0 |
8 |
5 |
0 |
4 |
0 |
0 |
0 |
4 |
0 |
0 |
10 |
5 |
0 |
12 |
5 |
0 |
12 |
0 |
0 |
8 |
0 |
0 |
2 |
0 |
0 |
0 |
5 |
0 |
0 |
10 |
10 |
5 |
16 |
10 |
5 |
12 |
0 |
0 |
8 |
0 |
0 |
4 |
0 |
0 |
0 |
6 |
0 |
0 |
10 |
5 |
0 |
10 |
5 |
0 |
10 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
Mean score |
10.6 |
25.3 |
22.5 |
8.6 |
3.1 |
0.0 |
||||||||||||
Cr- cornea, Ir- iris, Con-Conjunctivae |
||||||||||||||||||
Immediate: Discomfort was moderate with eyes tightly closed Comments: 10 min: Slight to moderate erythema; very slight to slight edema 1 Hr.: slight to moderate erythema ; very slight to slight edema 24 Hr.: area of barely perceptible corneal dullness, iris reaction to light was sluggish, moderate to severe erythema very slight to slight edema, copious discharge containing much whitish exudates. 48 - 120 Hr.: Gradually improvement. 168 Hr.: All scored zero.
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The chemical Vanillin (CAS No: 121-33-5) was considered to be mildly irritating to the eyes of six New Zealand White rabbits.
- Executive summary:
An eye irritation test of Vanillin (CAS No: 121-33-5) was performed in six New Zealand White rabbits to assess its eye irritation potential.
The Vanillin was applied as finely ground powder at a dose equivalent to 55 mg (0.1 ml) for 24 hours and reactions were scored at 24 , 48 and 72 hours according to Federal Hazardous Substances Act (FHSA).
Mild irritating effects were observed with the irritation score of 18.8 (out of maximum score of 110). All scored zero after 168 hours.
Since the chemical caused slight discomfort and ocular lesions during the 72 hours observation period, the chemical Vanillin (CAS No: 121-33-5) was considered to be mildly irritating to the eyes of six New Zealand White rabbits
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