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EC number: 246-922-9 | CAS number: 25378-22-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1993-09-13 to 1993-11-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restrictions because it was conducted according to GLP guidance and was generally in accordance with OECD 420 guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Octadecene
- EC Number:
- 248-205-6
- EC Name:
- Octadecene
- Cas Number:
- 27070-58-2
- IUPAC Name:
- octadec-1-ene
- Details on test material:
- - Name of test material (as cited in study report): C18 Isomerised Olefin
- Substance type: C18 isomerised olefin
- Physical state: Clear colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague Dawley, Inc., Houston, Texas
- Age at study initiation: Young adult
- Weight at study initiation: Males (211 to 228 grams); Females (194 to 208 grams)
- Fasting period before study: 16 hours
- Housing: One per cage; Suspended , wire bottom, stainless steel
- Diet (e.g. ad libitum): Purina Formulab Chow #5008; ad libitum
- Water (e.g. ad libitum): Tap, ad libitum
- Acclimation period: 5 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5.88 mL/kg equivalent to 5050 mg/kg
- Doses:
- 5050 mg/kg
- No. of animals per sex per dose:
- 5 males and females
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Three times on day the test chemical was administered and at least once daily thereafter until study termination on day 14
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs and body weight - Statistics:
- Statistical analysis, if performed, is not presented in the study report.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 050 other: mg/kg
- Mortality:
- No mortality was observed during the course of the study.
- Clinical signs:
- other: Notable observations included diarrhoea, piloerection and polyuria.
- Gross pathology:
- No observable abnormalities were noted.
Any other information on results incl. tables
Body weight gain was unaffected as a result of exposure to octadecene. Toxicological and pharmacological signs were not noted. Notable observations included diarrhoea, piloerection, and polyuria. Gross necropsy at study termination revealed no observable abnormalities. None of the treated animals died during the course of the study. Based on these results, the acute oral LD50 for octadecene in Sprague Dawley rats is > 5050 mg/kg (5.88 mL/kg).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Not classified because LD50 is greater than the requirements for a Category 4 toxicant (2000 mg/kg) Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 for octadecene is greater than 5050 mg/kg.
- Executive summary:
In an acute oral toxicity study, five male and female young adult Sprague-Dawley rats were administered 5050 mg/kg (5.88 mL/kg) of octadecene via oral intubation. Following treatment, the animals were observed for toxicological and pharmacological effects and mortality at least three times on the day of treatment and at least once daily until study termination on day 14. Individual body weights were noted prior to treatment and on days 7 and 14. Animals were sacrificed for necropsy on day 14.
Body weight gain was unaffected as a result of exposure to octadecene. Toxicological and pharmacological signs were not noted. Notable observations included diarrhoea, piloerection, and polyuria. Gross necropsy at study termination revealed no observable abnormalities. None of the treated animals died during the course of the study. Based on these results, the acute oral LD50 for octadecene in Sprague Dawley rats is > 5050 mg/kg (5.88 mL/kg).
This study received a Klimisch score of 1 and is classified as “reliable without restrictions” because it was conducted according to GLP guidance and was generally in accordance with OECD 420 guidelines. This study will influence the DNEL(s).
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