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EC number: 217-614-1 | CAS number: 1908-87-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted prior to GLP similar to OECD guideline 401 on the registered substance itself. The method is to be considered scientifically reasonable with minor deficiencies in documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- test conducted prior to GLP implementation
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-methylthiazolidine-2-thione
- EC Number:
- 217-614-1
- EC Name:
- 3-methylthiazolidine-2-thione
- Cas Number:
- 1908-87-8
- Molecular formula:
- C4H7NS2
- IUPAC Name:
- 3-methyl-1,3-thiazolidine-2-thione
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Substance type: pure substance
- Analytical purity: chemically pure
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar-II
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann animal breeder (Kirchborchen, Paderborn district) and Gierlich animal breeder (Bochum)
- Weight at study initiation: 160-210g
- Housing: macrolon cages, Type III
- Diet (e.g. ad libitum): Altromin R Standard diets (Altromin GmbH, Lage/Lippe) ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1, 2, 5, 10 , 20, 24, 30, 40%
- Amount of vehicle (if gavage): 0.5ml / 100 g bw - Doses:
- 50, 100, 250, 500, 1000, 1200, 1500, 2000 mg/kg (males; females only 50-1500 mg/kg)
- No. of animals per sex per dose:
- 15
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- The determination of the average lethal dose (LD50) was made using a Probit analysis (FINK und HUND, Arzneimittelforschung 15, 624, 1965).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 218 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 098 - 1 337
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 203 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 086 - 1 331
- Mortality:
- See 'Any other information on results incl. tables'
- Clinical signs:
- other: Appearance of poisoning: Symptoms of poisoning in the form of reduced general well-being, difficult breathing, reduced reflexes and lying on the stomach began 2 minutes to 24 hours after the application with the rats. The difficult breathing lasted up to
- Gross pathology:
- The livers of the dead animals exhibited a spotty appearance when sectioned.
Any other information on results incl. tables
Table 1: Results
Dose / mg/kg |
Conc. in vehicle / % |
Toxicol. Results after 14 d* |
Symptoms of poisoning |
Occurence of Death after |
|
Start |
End |
||||
Male Rats |
|||||
50 |
1 |
0/0/15 |
- |
- |
- |
100 |
2 |
0/15/15 |
24 h |
2 d |
- |
250 |
5 |
0/15/15 |
24 h |
4 d |
- |
500 |
10 |
0/15/15 |
1 h |
9 d |
- |
1000 |
20 |
3/15/15 |
16 min |
9 d |
1 – 6 d |
1200 |
24 |
7/15/15 |
10 min |
10 d |
1 – 2 d |
1500 |
30 |
12/15/15 |
4 min |
12 d |
1 – 2 d |
2000 |
40 |
15/15/15 |
2 min |
- |
1 – 2 d |
Female Rats |
|||||
50 |
1 |
0/0/15 |
- |
- |
- |
100 |
2 |
0/15/15 |
24 h |
2 d |
- |
250 |
5 |
0/15/15 |
24 h |
3 d |
- |
500 |
10 |
0/15/15 |
1.5 h |
9 d |
- |
1000 |
20 |
3/15/15 |
20 min |
7 d |
1 – 2 d |
1200 |
24 |
7/15/15 |
15 min |
7 d |
1 – 2 d |
1500 |
30 |
13/15/15 |
15 min |
9 d |
1 – 2 d |
*1stNumber = Number of dead animals
2ndNumber = Number of animals with symptoms
3rdNumber = Number of animals used
Highest dose without finding (m/f): 50 mg/kg
Lowest lethal dose (m/f): 1000 mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The study was conducted prior to GLP similar to OECD guideline 401 on the registered substance itself. The method is to be considered scientifically reasonable with minor deficiencies in documentation. Hence, the results can be considered as sufficiently reliable to assess the acute oral toxicity in rats. The determined LD50 values are 1218 mg/kg bw (males) resp. 1203 mg/kg bw (females). The results for both sexes are hence consistant and suitable to determine the classification of N-Methyl-2-thion-thiazolidine. According to Regulation (EC) No. 1272/2008, the substance needs to be classified as acute toxic cat. IV.
- Executive summary:
In an acute oral toxicity study similar to OECD guideline 401, groups of Wistar-II rats (15/sex/dose) were given a single oral dose N-Methyl-2-thion-thiazolidine in polyethylene glycol 400 at doses of 50, 100, 250, 500, 1000, 1200, 1500, 2000 mg/kg (males; females only 50-1500 mg/kg) and observed for 14 days. The following oral LD50 were determined:
Males = 1218 mg/kg bw (95% C.I. 1098 - 1337)
Females = 1203 mg/kg bw (95% C.I. 1086 - 1331)
Symptoms of poisoning were a significant reduction of the general well-being, difficult breathing and reduction of the reflexes. Mortality occurred after 8 minutes to 6 days.
N-Methyl-2-thion-thiazolidine is of slight toxicity based on the LD50 in females, leading to the classification as acute toxic Cat. IV according to Regulation (EC) No. 1272/2008.
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