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EC number: 219-307-8 | CAS number: 2408-20-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Subacute repeated dose oral toxicity study was performed to determine the oral toxic nature of Allyl propionate upon repeated exposure for 13 weeks. The study was performed using rats. The test chemical was mixed with feed at dose levels of 18 mg/Kg bw and fed to rats for 13 weeks. During the study, the animals were observed for hepatotoxicity. No signs of hepatic toxicity were noted at the mentioned dose level. Based on the data available, the No Observed Adverse Effect Level (NOAEL) for Allyl propionate is considered to be 18 mg/Kg bw/day.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from WHO report
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Subchronic repeated dose oral toxicity study was performed to determine the oral toxic nature of Allyl propionate upon repeated exposure for 13 weeks using rats
- GLP compliance:
- not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material: Allyl propionate
- Molecular formula: C6H10O2
- Molecular weight: 114.143 g/mol
- Substance type: Organic
- Physical state: No data
- Impurities (identity and concentrations): No data - Species:
- rat
- Strain:
- not specified
- Details on species / strain selection:
- No data
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
- Route of administration:
- oral: feed
- Details on route of administration:
- No data
- Vehicle:
- other: Feed
- Details on oral exposure:
- PREPARATION OF DOSING SOLUTIONS: The test chemical was mixed with feed at dose level of 18 mg/Kg bw/day
DIET PREPARATION
- Rate of preparation of diet (frequency): No data
- Mixing appropriate amounts with (Type of food): No data
- Storage temperature of food: No data
VEHICLE
- Justification for use and choice of vehicle (if other than water): Feed
- Concentration in vehicle: 18 mg/Kg bw/day
- Amount of vehicle (if gavage): No data
- Lot/batch no. (if required): No data
- Purity: No data - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- No data
- Remarks:
- 18 mg/Kg bw/day
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Positive control:
- No data
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
- Time schedule: No data
- Cage side observations checked in table [No.?] were included. No data
DETAILED CLINICAL OBSERVATIONS: No data
- Time schedule: No data
BODY WEIGHT: No data
- Time schedule for examinations: No data
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study): No data
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No data
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: No data
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No data
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data
- Time schedule for examinations: No data
OPHTHALMOSCOPIC EXAMINATION: No data
- Time schedule for examinations: No data
- Dose groups that were examined: No data
HAEMATOLOGY: No data
- Time schedule for collection of blood: No data
- Anaesthetic used for blood collection: No data
- Animals fasted: No data
- How many animals: No data
- Parameters checked in table [No.?] were examined. No data
CLINICAL CHEMISTRY: No data
- Time schedule for collection of blood: No data
- Animals fasted: No data
- How many animals: No data
- Parameters checked in table [No.?] were examined. No data
URINALYSIS: No data
- Time schedule for collection of urine: No data
- Metabolism cages used for collection of urine: No data
- Animals fasted: No data - Parameters checked in table [No.?] were examined. No data
NEUROBEHAVIOURAL EXAMINATION: No data
- Time schedule for examinations: No data
- Dose groups that were examined: No data
- Battery of functions tested: sensory activity / grip strength / motor activity / other: No data
OTHER: The animals were observed for hepatotoxicity - Sacrifice and pathology:
- No data
- Other examinations:
- No data
- Statistics:
- No data
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- no effects observed
- Description (incidence and severity):
- Clinical signs and mortality: No data
Body weight and weight gain: No data
Food consumption and compound intake: No data
Food efficiency: No data
Water consumption and compound intake: No data
Opthalmoscopic examination: No data
Haematolog: No data
Clinical chemistry: No data
Urinanalysis: No data
Neurobehaviour: No data
Organ weights: No data
Gross pathology: No data
Histopathology: No data - Details on results:
- No data
- Dose descriptor:
- NOAEL
- Effect level:
- 18 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: No hepatotoxicity was noted at the mentioned dose level
- Critical effects observed:
- no
- Organ:
- liver
- Conclusions:
- The No Observed Adverse Effect Level (NOAEL) for Allyl propionate is considered to be 18 mg/Kg bw/day.
- Executive summary:
Subchronic repeated dose oral toxicity study was performed to determine the oral toxic nature of Allyl propionate upon repeated exposure for 13 weeks. The study was performed using rats. The test chemical was mixed with feed at dose levels of 18 mg/Kg bw and fed to rats for 13 weeks. During the study, the animals were observed for hepatotoxicity. No signs of hepatic toxicity were noted at the mentioned dose level. Based on the data available, the No Observed Adverse Effect Level (NOAEL) for Allyl propionate is considered to be 18 mg/Kg bw/day.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 18 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Data is from WHO Technical series
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Repeated dose toxicity: Oral
Data available for the target chemical was reviewed to determine the toxic nature of Allyl propionate uon repeated exposure by oral route. The study is as mentioned below:
Subacute repeated dose oral toxicity study was performed to determine the oral toxic nature of Allyl propionate upon repeated exposure for 13 weeks. The study was performed using rats. The test chemical was mixed with feed at dose levels of 18 mg/Kg bw and fed to rats for 13 weeks. During the study, the animals were observed for hepatotoxicity. No signs of hepatic toxicity were noted at the mentioned dose level. Based on the data available, the No Observed Adverse Effect Level (NOAEL) for Allyl propionate is considered to be 18 mg/Kg bw/day.
In another study ( Flavor and Extract Manufacturers' Association, 1985) for the target chemical, subchronic repeated dose oral toxicity study was performed to determine the oral toxic nature of Allyl propionate upon repeated exposure for 90 days. The study was performed using male and female Charles River CD rats. The test chemical was mixed with the diet 10.1% on gum arabic to give an average daily intake of 15.54 (males) and 18.10 (females) mg/kg. The animals were observed for body weight and food consumption changes, hematological, blood chemical and urine analysis. The animals were autopsied and gross and histopathology was performed. Weekly measurement of body weights and food intake revealed a significant decrease in body weights in both sexes.Hematological examination, blood chemical determinations and urinanalysis conducted at weeks 6 and 12 revealed decreased hemoglobin levels in males only. Organ weights at autopsy were normal. Gross and histopathological examination revealed no dose-related abnormalities. Based on the observations made, the No Observed Adverse Effect Level (NOAEL) for Allyl propionate is considered to be 15.54 mg/Kg for males and 18.10
mg/Kg for females.
Study for 50 -60% structurally similar read across chemical mentioned in Food and Agriculture Organization of the United Nations and WHO (1968) was also reviewed. In a repeated oral toxicity study, male and female rats were administered 14.4 mg/kg bw of Ethyl butyrate (RA CAS no 105 -54 -4) in diet for 12 weeks. Based on the results, no adverse effects were noted in the animals. Therefore, the No Observed Adverse Effect Level (NOAEL) was considered to be 14.4 mg/kg bw when male and female rats were exposed to Ethyl butyrate for 12 weeks by diet.
Based on the data available for the target chemical, Allyl propionate does not exhibit toxic nature upon repeated exposure by oral route. Hence the test chemical is not likely to classfy as toxicant upon repeated exposure by oral route.
Justification for classification or non-classification
Based on the data available for the target chemical, Allyl propionate (CAS no 2408 -20 -0 ) does not exhibit toxic nature upon repeated exposure by oral route. Hence the test chemical is not likely to classfy as toxicant upon repeated exposure by oral route.
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