Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 1985
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
To evaluate the acute toxicity by oral route, 6 rats were exposed by gavage to 5000 mg/kg bw of test substance.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
reaction mass of decyl acrylate and octyl acrylate
EC Number:
911-295-9
Molecular formula:
C11H20O2 and C13H24O2
IUPAC Name:
reaction mass of decyl acrylate and octyl acrylate
Test material form:
liquid

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
5000 mg/kg (5.7 ml/kg)
No. of animals per sex per dose:
6
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD0
Effect level:
> 5 000 mg/kg bw
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
no mortality was observed
Clinical signs:
no data
Body weight:
no data
Gross pathology:
No sign of gross toxicity was observed

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
No mortality was observed after an acute exposure of 5000 mg/kg bw to 6 rats.
Executive summary:

To evaluate the acute toxicity by oral route, 6 rats were exposed by gavage to 5000 mg/kg bw of test substance. No mortality were observed after the administration during the study, and o sign of gross toxicity were observed at the autopsy.

In conclusion, the oral LD0 of the test substance is higher than 5000 mg/kg bw.