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Diss Factsheets
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EC number: 230-256-0 | CAS number: 6990-06-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Weight of evidence:
Acute toxicity: oral.: Based on the available data, the oral LD50 for fusidic acid was determined to be 1070.5 mg/kg + 21.9 mg/kg body weight in mice.
Acute toxicity: oral.: Based on the available data, the oral LD50 for fusidic acid was determined to be 1500 mg/kg body weight in mice.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- No data on method, no data on GLP
- Principles of method if other than guideline:
- Standard protocol described in Pharmacopea Nordica. 1969, vol. IV: 30.3 - 30.8
- GLP compliance:
- not specified
- Species:
- mouse
- Strain:
- CBA
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 1 070.5 - <= 1 092.4 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No data available.
- Clinical signs:
- No data available.
- Body weight:
- No data available.
- Gross pathology:
- No data available.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 in mice is 1070.5 mg/kg + 21.9 mg/kg.
- Executive summary:
The acute oral toxicity of the test substance was evaluated on mice. According to the results, the oral LD50 is 1070.5 mg/kg + 21.9 mg/kg.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- No data on method, no data on GLP.
- Principles of method if other than guideline:
- No data on method.
- GLP compliance:
- not specified
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No data available.
- Clinical signs:
- No data available.
- Body weight:
- No data available.
- Gross pathology:
- No data available.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 in mice is 1500 mg/kg.
- Executive summary:
The acute oral toxicity of the test substance was evaluated on mice. According to the results, the oral LD50 is 1500 mg/kg body weight.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 070.5 mg/kg bw
- Quality of whole database:
- Diverse oral-DL50 from publications are taken as a weight of evidence. The results of the whole database lead to the same classification of the substance according to CLP regulation.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Weight of evidence:
Acute toxicity: oral.: The acute oral toxicity of the test substance was evaluated on mice. GLP study not specified. According to the results, the oral LD50 is 1070.5 mg/kg + 21.9 mg/kg bw.
Acute toxicity: oral.: The acute oral toxicity of the test substance was evaluated on mice. GLP study not specified. According to the results, the oral LD50 is 1500 mg/kg body weight bw.
Justification for classification or non-classification
Based on the available data the oral LD50 was determined to be 1070.5 mg/kg + 21.9 mg/kg bw in mice. Fusidic acid is classified for Acute oral toxicity Category 4 according to CLP Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.