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Diss Factsheets
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EC number: 264-713-0 | CAS number: 64164-17-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- WCA-003/4-20/G
- Analytical monitoring:
- yes
- Details on sampling:
- Sampling at test start before distribution to replicates and sampling of aged test solution by pooling replicate concentration samples.
- Vehicle:
- no
- Details on test solutions:
- - Stock concentration: 220 mg/L
- Stock solution preparation: stirred for 1h at ca. 20⁰C - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Strain: Clone V
- Source: Fraunhofer IME
- Age at study initiation (mean and range, SD): 4-24h
- Feeding during test: no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 70 - 120 mg/L as CaCO3 - below recommended range; historical conditions at laboratory indicate that this range is acceptable for the Daphnia magna strain used at the IME
- Test temperature:
- 20.3⁰C
- pH:
- 7.8- 8.2
- Dissolved oxygen:
- 8.4 - 8.9mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 4.3. 9.4. 20.7. 45.5. 100. 220 mg/L
Measured concentrations at 0h: 4.28, 8.99, 20.38, 47.23, 106.96, 233.15 mg/L
Measured concentrations at 48h: 4.58, 10.67, 22.68, 49.72, 104.97, 231.22 mg/L
Mean measured concentrations were 96 - 107% of nominal for freshly prepared test solutions and 105 - 114% in aged test solutions therefore nominal concentrations were used for reporting of results. - Details on test conditions:
- - Test vessel: glass beaker
- Type: open
- Material, size, headspace, fill volume: 50mL
- Aeration: no
- No. of organisms per vessel:5
- No. of vessels per concentration (replicates):4
- Control: dilution water
- Light intensity: 10.7-11.1 uE/m2/s
- Light/dark cycle: 16/8
All water quality guidelines (except for water hardness) recommended by the OECD guideline were met. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 81.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CL: 31.8-324.3 mg Rh/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 45.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC10
- Effect conc.:
- 28.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CL: 0.4-56.3 mg Rh/L
- Details on results:
- No significant signs of disease or stress were observed.
- Results with reference substance (positive control):
- 24h EC50 immobilisation with K2Cr2O7: 1.19 mg/L
95% CL: 1.05-1.36 mg/L - Reported statistics and error estimates:
- 95% confidence intervals calculated by Probit-analysis, assuming log-normal distribution of the values.
Statistical calculations performed with ToxRat. - Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 was determined to be 81.3 mg/L.
- Executive summary:
The influence of diammonium sodium hexakis (nitrito-N) rhodate on the mortality of Daphnia magna was investigated according to OECD guideline 202 and EC method C.2 (Simon 2014). The daphnids were placed in water containing the test item in a nominal concentration range of 4.3 to 220 mg/L, and as measured test concentrations did not deviate by more than 20% of nominal, nominal concentrations were used for reporting of results. The test was conducted under static conditions for 48 h. The study was conducted in accordance with GLP and all validity criteria were met. This study has been given a reliability rating of 1 as it is well-documented and adheres to guideline procedures.
No significantly increased mortality was determined up to a concentration of 45.5 mg/L. The EC50 for the tested species was found to be 81.3 (95 % CL: 31.8 – 324.3) mg/L.
Reference
Mortality | |
NOEC | 45.5 |
LOEC | 100 |
EC10 (95% CL) | 28.3 (0.4 -56.3) |
EC20 (95% CL) | 40.6 (2.2 -78.6) |
EC50 (95% CL) | 81.3 (31.8 -324.3) |
Description of key information
The EC50 was determined to be 81.3 mg L-1.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 81.3 mg/L
Additional information
Acute toxicity to Daphnia was assessed according to OECD guideline 202 and EC method C.2 (Simon 2014). The daphnids were placed in water containing the test item in a nominal concentration range of 4.3 to 220 mg L-1, and as measured test concentrations did not deviate by more than 20% of nominal, nominal concentrations were used for reporting of results. The test was conducted under static conditions for 48 h. The study was conducted in accordance with GLP and all validity criteria were met. This study has been given a reliability rating of 1 as it is well-documented and adheres to guideline procedures.
No significantly increased mortality was determined up to a concentration of 45.5 mg L-1. The EC50 for the tested species was found to be 81.3 mg test item L-1 (95 % CL: 31.8 – 324.3).
For PNEC derivation all data for rhodium(III) substances has been pooled and the PNEC values derived based on the most sensitive result. In the risk assessment, emissions of different rhodium substances are not analysed separately and therefore measured environmental concentrations are available based on total rhodium concentrations. As the measured emissions data is not apportioned to a particular rhodium(III) substance, a single set of PNECs covering all rhodium substances in the same oxidation state is considered to be the most appropriate approach for conducting the risk assessment. For aquatic PNECs the lowest EC50 value is for the rhodium(III) substance rhodium(III) chloride. There is some indication that rhodium substances containing a chloro ligand may be more toxic than those without, and therefore using the value for rhodium trichloride as the key value for PNEC derivation for all rhodium(III) substances is likely to be worst case. The value taken forward for PNEC derivation is therefore a 48-hour EC50 of 0.290 mg Rh L-1, based on a study using rhodium chloride (hydrate).
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