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Diss Factsheets
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EC number: 217-682-2 | CAS number: 1929-82-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity oral:
Several LD50 values were cited in peer reviewed and authorative secondary sources with no information on methodology as dose decriptors were provided only. Based on these results, the acute oral toxicity of test item was low to moderate with the lowest LD50 value of 713 mg/kg bw derived for the species mouse (Yano et al., 2008).
Acute toxicity inhalation:
A LD50 value of > 0.03 mg/L air was cited in an authorative secondary source (US-EPA, 2005) with no information on methodology as dose descriptor was provided only.
Acute toxicity dermal:
Two contradicting dose descriptors for were cited in two authorative secondary sources for the species rabbit (LD50 rabbit: > 2000 mg/kg bw (US-EPA, 2005) and 850 mg/kg bw (Health Council of the Netherlands, 2002).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed secondary source with dose decriptor provided only.
- Principles of method if other than guideline:
- Secondary literature source no data about the method was available.
- GLP compliance:
- not specified
- Species:
- mouse
- Strain:
- not specified
- Sex:
- female
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 713 mg/kg bw
- Based on:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 713 mg/kg bw
- Quality of whole database:
- Data origins from peer reviewed secondary source with dose decriptor provided only.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Authorative secondary source with dose decriptor provided only. Original study report was not available.
- Principles of method if other than guideline:
- Secondary literature source no data about the method was available.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 0.03 mg/L air
- Remarks on result:
- other: no effects (technically limited atmospheric conc.)
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 0.03 mg/m³
- Quality of whole database:
- Data origins from peer reviewed secondary source with dose decriptor provided only.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Authorative secondary source with dose decriptor provided only. Original study report was not available.
- Principles of method if other than guideline:
- Secondary literature source no data about the method was available.
- GLP compliance:
- not specified
- Species:
- rabbit
- Sex:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute toxicity oral:
Several LD50 values were cited in peer reviewed and authorative secondary sources with no information on methodology provided (dose descriptor cited only). The acute oral toxicity of test item was regarded as low to moderate based on the following oral LD50 values: LD50 mouse: 713 mg/kg bw (Yano et al., 2008); LD50 rat: 1072 mg/kg bw for males, 1231 mg/kg bw for females (Yano et al., 2008), 940 mg/kg bw (Health Council of the Netherlands, 2002); LD50 rabbit: 850 mg/kg bw (Health Council of the Netherlands, 2002).
Acute toxicity inhalation:
A LD50 value of > 0.03 mg/L air was cited in an authorative secondary source (US-EPA, 2005) with no information on methodology (dose descriptor provided only). No adverse effects were observed.
Acute toxicity dermal:
Two contradicting dose descriptors were cited in two authorative secondary sources for the species rabbit. The LD50 for rabbits was cited to be greater than 2000 mg/kg bw (US-EPA, 2005) and to be 850 mg/kg bw (Health Council of the Netherlands, 2002). For classification and labelling the LD50 of US-EPA evaluation was used.
Justification for selection of acute toxicity – oral endpoint
Lowest dose descriptor available.
Justification for selection of acute toxicity – inhalation endpoint
Sole reference available.
Justification for selection of acute toxicity – dermal endpoint
Data origins from peer reviewed secondary source with dose decriptor provided only.
Justification for classification or non-classification
Acute oral toxicity
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under Directive 67/548/EEC. As a result and according to the harmonised Annex I classification the substance is considered to be classified for acute oral toxicity Xn R22: Harmful if swallowed under Directive 67/548/EEC, as amended for the 31st time in Directive 2009/2/EG.
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. As a result and according to the harmonised Annex VI classification the substance is considered to be classified for acute oral toxicity cat. 4, H302: Harmful if swallowed under Regulation (EC) No 1272/2008, as amended for the sixth time in Regulation (EC) No 605/2014.
Acute inhalation toxicity
Dangerous Substance Directive (67/548/EEC)
The available study is considered reliable and suitable for classification purposes under Directive 67/548/EEC. As a result and according to the harmonised Annex I classification the substance is not considered to be classified for acute inhalation toxicity under Directive 67/548/EEC, as amended for the 31st time in Directive 2009/2/EG.
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. As a result and according to the harmonised Annex VI classification the substance is not considered to be classified for acute inhalation toxicity under Regulation (EC) No 1272/2008, as amended for the sixth time in Regulation (EC) No 605/2014.
Acute dermal toxicity
Dangerous Substance Directive (67/548/EEC)
According to the harmonised Annex I classification the substance is not considered to be classified for acute dermal toxicity under Directive 67/548/EEC, as amended for the 31st time in Directive 2009/2/EG.
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
According to the harmonised Annex VI classification the substance is not considered to be classified for acute dermal toxicity under Regulation (EC) No 1272/2008, as amended for the sixth time in Regulation (EC) No 605/2014.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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