Registration Dossier
Registration Dossier
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EC number: 226-375-2 | CAS number: 5382-23-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study in Rat for CAS no: 109-01-3
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn).,2017
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Henry F. Smyth Jr., Charles P. Carpenter, Carrol S. Well, Urbano C. Pozzani & Jean A. Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 1962, 23:2, 95-107
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of 1-Methylpiperazine was performed in Rat
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpiperazine
- EC Number:
- 203-639-5
- EC Name:
- 1-methylpiperazine
- Cas Number:
- 109-01-3
- Molecular formula:
- C5H12N2
- IUPAC Name:
- 1-methylpiperazine
- Details on test material:
- - Name of test material: 1-Methylpiperazine
- Molecular formula: C5H12N2
- Molecular weight: 100.16 g/mol
- Substance type: Organic
- Physical state: No data available
- Impurities (identity and concentrations): No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 1-Methylpiperazine
- Molecular formula: C5H12N2
- Molecular weight: 100.16 g/mol
- Substance type: Organic
- Physical state: No data available
- Impurities (identity and concentrations): No data available
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation:4-5 weeks
- Weight at study initiation:90-120g
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): Rockland rat diet, complete.
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs): No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data available
- Doses:
- 2560mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- No data available- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:No data available
- Necropsy of survivors performed:no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:No data available - Statistics:
- the most probable LD,, value and its fiducial range are estimated by the method of Thompsono using the Tables of Weil
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 560 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be 2560mg/kg body weight. When rats were treated with 1-Methylpiperazine (109-01-3) orally.
- Executive summary:
Acute oral toxicity study was done in5 Carworth-Wistar male rat using1-Methylpiperazine(109-01-3).All the animals having weight rang 90-120g and age 4-5 weeks and provided by Rockland rat diet, The test material in dose concentration 2560 given undiluted by oral intubation and observed for 14 days .50% mortality was observed at dose 2560mg/kg bw. HenceLD50 was considered to be2560mg/kgbody weight. When rats were treated with1-Methylpiperazine(109-01-3)orally.
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