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EC number: 681-644-5 | CAS number: 136369-04-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- potassium 5-amino-1H-1,2,3,4-tetrazol-1-ide
- Cas Number:
- 136369-04-5
- Molecular formula:
- CH2KN5
- IUPAC Name:
- potassium 5-amino-1H-1,2,3,4-tetrazol-1-ide
- Test material form:
- solid: particulate/powder
- Details on test material:
- Batch no.: 08KI030
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Healthy female rats were housed by group of three in solid-bottomed clear polycarbonate cages with a stainless steel mesh Iid. Each cage contains sawdust bedding which was changed at least 2 times a week. Each cage was installed in conventional air conditioned animal husbandry. The temperature and relative humidity of the main test were controlled to remain within target ranges of 19 to 25°C and 30 to 70%, respectively. Any occasional deviations from these targets were considered not to have affected the purpose or integrity ofthe study. The rate of air exchange was approximately fifteen changes per hour and the lighting was controlled by a time switch to give twelve hours continuous light (07.00 to 19.00) and twelvehours darkness. Drinking water (tap-water from public distribution system) and foodstuff were supplied freely. Food was removed at D-1 and then redistributed 4 hours after the test item administration. Microbiological and chemical analyses of the water were carried out once every six months by the Institut Europeen de l'Environnement de Bordeaux (I.E.E.B.).
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The animals of the treated group, received an effective dose of 2000 mglkg body weight of the test item 5-Aminotetrazol Potassium, diluted in distilled water and administered by gavage under a volume of 10 mL/kg body weight using a suitable syringe graduated fitted with an oesophageal metal canula.
- Doses:
- 2000 mg/kg per body weight
- No. of animals per sex per dose:
- 2 x 3
- Control animals:
- no
- Details on study design:
- Systematic examinations were carried out to identify any behavioural or toxic effects on the major physiological functions 14 days after administration of the test item. This examination focuses particularly on a Iist of symptoms, recorded as "present" or "absent" on the observation sheet. These observations were compared to control data. Observations and a mortality repmt were then carried out every day for 14 days. The animals were weighed on day D0 (just before administering the test item) then on D2, D7, and D14. Weight changes were calculated and recorded. On D14, the animals were anaesthetised with sodium pentobarbital and administration continued to fatallevels. Macroscopic observations were entered on individual autopsy sheets. Only those organs likely to be modified in cases of acute toxicity were examined. Those presenting macroscopic anomalies can be removed and preserved in view to microscopic examinations.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- other: No clinical signs related to the administration ofthe test item were observed.
- Gross pathology:
- The macroscopical examination ofthe animals at the end ofthe study did not reveal treatment-related changes.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LDso of the test item 5-Aminotetrazol Potassium is high er than 2000 mglkg body weight by oral raute in the rat. In accordance with the OECD guideline n°423, the LD50 of the test item may be considered higher than 5000 mglkg body weigbt by oral raute in the rat. According to the criteria for classification, packaging and labelling of dangeraus substances and preparations in accordance with the E.E.C. Directives 67/548, 2001/59 and 99/45, the test item 5-Aminotetrazol Potassium doesn't need tobe classified. No symbol and risk phrase are required. In accordance with the Globally Ha1monized System (Regulation (EC) No 1272/2008), the lest item doesn't need to be classified in category 4. No signal work and hazard statement are required.
- Executive summary:
The test item 5-Aminotetrazol Potassium was admiuistered by oral route to a group of 6 female Sprague Dawley rats at the siugle dose of 2000 mg/kg body weight. The experimental protocol was established on the basis of the official method as defined iu the O.E.C.D. guideliue N° 423 dated December 17th, 2001 and the test method B.lter ofthe Council regulation No 440/2008. No mortality occurred duriug the study. No clinical sigus related to the administration ofthe test item were observed. The body weight evolution of the animals remairred normal throughout the study, similar between treated and control animals. The macroscopical examination ofthe animals at the end ofthe study did not reveal treatment-related changes. In conclusion, the LD50 of the test item 5-Aminotetrazol Potassium is higher than 2000 mg/kg body weight by oral route iu the rat. In accordance with the OECD goideiirre n°423, the LD50 of the test item may be considered higher than 5000 mg/kg body weight by oral raute in the rat. Accordiug to the criteria for classification, packagiug and labeHing of dangerous substances and preparations in accordance with the E.E.C. Directives 67/548, 2001/59 and 99/45, the test item 5-Aminotetrazol Potassium doesn't need to be classified. No symbol and risk phrase are required. In accordance with the Globally Harmonized System (Regulation (EC) No 1272/2008), the test item doesn't need tobe classified in category 4. No sigual word and hazard statement are required.
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