Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 228-940-9 | CAS number: 6375-55-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From April 21 to 23, 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 1992
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on test solutions:
- Preparation of the stock solution and dilution
The test substance was stirred in M4 medium for about 20 hours at appr. 20 ± 2 °C. Undissolved test substance was removed by means of centrifugation (appr. 20 minutes at about 17700 G). The nominal concentration of the eluate was 100 mg/l. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna STRAUS 1820
- Source: Institut National de Recherche Chimique AppIiquée, France
- Age of parental stock (mean and range, SD): 2 - 4 weeks
- Age of the animais at the start of the test 2 - 24 hours (starting with the 3. instar)
- Feeding during test: none - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 2,20 - 3,20 mmol/l
- Test temperature:
- 18 - 22 °C (max. temperature difference 2 °C)
- pH:
- 7.5 - 8.5
- Conductivity:
- 550 - 650 µS/cm
- Nominal and measured concentrations:
- 12.5, 25, 50, 100 mg/l nominal concentration
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Test tubes with fiat bottom
- Type (delete if not applicable): open / closed
- Material, size, headspace, fill volume: glass, nominal volume 20 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: water is prepared an the basis of an ultrapure, demineralized water with a conductivity < 0.05 µS/cm.
- Alkalinity: up to pH 4.3, 0,80 - 1,00 mmol/l
- Ca/mg ratio: about 4: 1
- Conductivity: 550 - 650 pS/cm
OTHER TEST CONDITIONS
- Photoperiod: Artificial Iight, type warm white (eg. OSRAM L58 W31) day : night-rhythm = 16 : 8 hours
- Light intensity: About 2 - 7 µE/(m2S) in the wave Iength of 400 - 700 nm - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 39.4 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 39.4 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 39.4 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- 39.4 mg/l measured concentration corresponding to 100 mg/l of nominal concentration.
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 (48h) > 39.4 mg/l ( >100 mg/l nominal)
- Executive summary:
Method
The acute toxicity of the test substance to Daphnia magna STRAUS was investigated in a 48-hour static test according to EEC Directive 92/32/EEC (December 1992). The test substance was tested in the range of concentrations between 12.5 mg/l and 100 mg/l. The dilution factor was 2.
lnstead of mortality the test criterion of the acute toxicity is immobilization of the daphnids after 48 hours of exposure which is expressed as EC (effect concentration). Those animals were considered to be immobile which were unable to swim within 15 seconds even after gentle agitation of the test vessel.
Results
EC50 (48h) > 39.4 mg/l ( >100 mg/l nominal )
Reference
Validity criteria:
- In the control the immobilization was ≤ 10%.
- In the controi no Daphnids were captured in a surface film.
- The O2-concentration was in all tested replicates > 3 mg/l.
- The EC50 (24h) of the control substance potassium dichromate was 1,29 mg/L. (Date of the last control experiment: 17.03.98)
Description of key information
EC50 (48h) > 39.4 mg/l ( >100 mg/l nominal)
Key value for chemical safety assessment
Additional information
The acute toxicity of the test substance to the water flea Daphnia magna STRAUS was investigated in a 48-hour static test according to EEC Directive 92/32/EEC (December 1992). The test substance was tested in the range of concentrations between 12,5 mg/l and 100 mg/l. The dilution factor was 2.
lnstead of mortality the test criterion of the acute toxicity is immobilization of the daphnids after 48 hours of exposure which is expressed as EC (effect concentration). Those animals were considered to be immobile which were unable to swim within 15 seconds even after gentle agitation of the test vessel.
EC50 (48h) > 39.4 mg/l ( >100 mg/l nominal)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.