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Diss Factsheets
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EC number: 200-926-7 | CAS number: 76-02-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- other: reference to the same publication
Reference
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- other: Reference to same publication
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Details on test solutions:
- Test solutions were prepared in well water having a total alkalinity of 138 mg/L. A photoperiod of 16h light/8h dark was maintained.
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- The fish were less than 1 year old.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 192 mg/L
- Test temperature:
- 20°C ± 1°C
- pH:
- 8.2
- Nominal and measured concentrations:
- No data
- Details on test conditions:
- TEST SYSTEM
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
Fish tests were conducted in 19-L jars containing 14 L of test solution.
The number of survivors in each test concentrations was monitored daily.
The 96h-LC50 (median lethal concentration, i.e., concentration lethal to 50% of the exposed animals) was calculated by means of the method of Litchfield and Wilcoxon. - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2 000 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No data
- Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Under the test conditions, the 96-hour LC50 was 2000 mg/L. Trichloroacetic acid is not harmful to fish.
- Executive summary:
The objective of the study was to determine the acute toxicity of Trichloroacetic acid (TCA) to Pimephales promelas.
The 96 -hour LC50 was determined to be 2000 mg/L.
In these test conditions, TCA is not harmful to fish.
Data source
Reference
- Reference Type:
- publication
- Title:
- Degradation of Diazinon by Sodium Hypochlorite. Chemistry and Aquatic Toxicity
- Author:
- William H. Dennis, Jr., Eugene P. Meier, William F. Randall, Alan B. Rosencrance and David H. Rosenblatt
- Year:
- 1 979
- Bibliographic source:
- Environmental Science & Technology, Volume 13, Number 5, May 1979, 594-598
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trichloroacetic acid
- EC Number:
- 200-927-2
- EC Name:
- Trichloroacetic acid
- Cas Number:
- 76-03-9
- Molecular formula:
- C2HCl3O2
- IUPAC Name:
- trichloroacetic acid
- Test material form:
- solid
- Details on test material:
- No data available
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- not specified
- Details on test solutions:
- Test solutions were prepared in well water having a total alkalinity of 138 mg/L. A photoperiod of 16h light/8h dark was maintained.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The daphnia were less than 24 h old.
Study design
- Test type:
- static
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 192 mg/L
- Test temperature:
- 20°C ± 1°C
- pH:
- 8.2
- Nominal and measured concentrations:
- No data
- Details on test conditions:
- TEST SYSTEM
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 12
Daphnia tests were performed in 205-mL beakers containing 200 mL of test solution.
The number of survivors in each test concentrations was monitored daily (swimming ability was the criterion for survival).
The 48h-EC50 (median effective concentration, i.e., concentration which immobilized 50% of the exposed animals) was calculated by means of the method of Litchfield and Wilcoxon. - Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2 000 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- No data
- Reported statistics and error estimates:
- No data
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 48-hour EC50 was 2000 mg/L. Trichloroacetic acid is not harmful to daphnia.
- Executive summary:
The objective of the study was to determine the acute toxicity of Trichloroacetic acid (TCA) to Daphnia magna.
The 48 -hour EC50 was determined to be 2000 mg/L.
In these test conditions, TCA is not harmful to daphnia.
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