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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Final Safety Assessment of Thiodipropionic Acid and Its Dialkyl Esters as Used in Cosmetics
Author:
Diamante et. al.
Year:
2010
Bibliographic source:
International journal of Toxicology

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Modified Draize test
Principles of method if other than guideline:
To assess the eye irritation potential of test chemical in rabbits.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Didodecyl 3,3'-thiodipropionate
EC Number:
204-614-1
EC Name:
Didodecyl 3,3'-thiodipropionate
Cas Number:
123-28-4
Molecular formula:
C30H58O4S
IUPAC Name:
didodecyl 3,3'-sulfanediyldipropanoate
Test material form:
solid
Details on test material:
Name of the test chemical: didodecyl 3,3'-sulfanediyldipropanoate [Dilauryl thiodipropionate]
Molecular Formula:C30H58O4S
Molecular Weight:514.85 g/mol
Substance Type: Organic
Physical State: Solid

Test animals / tissue source

Species:
rabbit
Strain:
other: New Zealand Albino
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
other: makeup foundation containing 0.05% Dilauryl thiodipropionate
Controls:
not specified
Amount / concentration applied:
an unspecified amount of a makeup foundation containing 0.05% Dilauryl thiodipropionate
Duration of treatment / exposure:
single exposure
Observation period (in vivo):
The rabbits were observed for signs of irritation (duration not mentioned).
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
9
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
None of the rabbits had ocular reactions to the test material at any of the observation times

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
None of the rabbits had ocular reactions to the test chemical at any of the observation times. Hence, the makeup foundation containing 0.05% of test chemical was considered not irritating to rabbit eyes under the conditions of the study.
Executive summary:

The eye irritation potential of test substance was assessed in rabbits according to Modified Draize method. An unspecified amount of a makeup foundation containing 0.05% of test substance was instilled into the eyes of 9 albino New Zealand White rabbits. The rabbits were observed for signs of irritation (duration not mentioned).

None of the rabbits had ocular reactions at any of the observation times. Hence, the makeup foundation containing 0.05% of test material was considered as not irritating to rabbit eyes under the conditions of the study.