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EC number: 219-264-5 | CAS number: 2398-37-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from publication .
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicological Assessment of Cyclopentyl Methyl Ether (CPME) as a Green Solvent
- Author:
- Kiyoshi Watanabe
- Year:
- 2 013
- Bibliographic source:
- Molecules 2013, 18, 3183-3194
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Principles of method if other than guideline:
- Skin sensitizing potential of of Cyclopentane, methoxy- was evaluated in mouse by LLNA mode.
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Cyclopentane, methoxy-
- EC Number:
- 611-360-9
- Cas Number:
- 5614-37-9
- Molecular formula:
- C6H12O
- IUPAC Name:
- Cyclopentane, methoxy-
Constituent 1
- Specific details on test material used for the study:
- Details on test material
- Name of test material (as cited in study report): Cyclopentyl methyl ether (Cyclopentane, methoxy-)
- Molecular formula: C6 H12 O
- Molecular weight : 100.159 g/mol
- Substance type: Organic
- Physical state: liquid
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: Harlan UK Ltd or
Charles River UK Ltd.
- Age at study initiation: No data available
- Weight at study initiation: No data available
- Housing: Each cage was made of stainless steel with stainless steel grid floors.
- Diet (e.g. ad libitum): rodent diet ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18–24 °C
- Humidity (%): 40–70%
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): 12 h (06:00–18:00 or 07:00–19:00)
Study design: in vivo (LLNA)
- Vehicle:
- not specified
- Concentration:
- 25, 50 and 100%
- No. of animals per dose:
- No data available
- Details on study design:
- Details on study design
PRE-SCREEN TESTS:
- Compound solubility: No data available
- Irritation: No data available
- Systemic toxicity: No data available
- Ear thickness measurements: No data available
- Erythema scores: No data available
MAIN STUDY
ANIMAL ASSIGNMENT AND TREATMENT
- Name of test method: The Local
Lymph Node Assay
- Criteria used to consider a positive response: The test substance is regarded as a sensitizer if at least one concentration of the chemical results in a 300% greater increase in 3HTdR incorporation compared to control values.
TREATMENT PREPARATION AND ADMINISTRATION:
In this assays, the concentration of Cyclopentane, methoxy- supplied were 25, 50 and 100%.
The proliferative response of the lymph node cells (LNC) from the draining auricular lymph node was assessed five days following the initial application, by measurement of the incorporation of 3H-thymidine by β-scintillation counting of LNC suspension. - Statistics:
- No data available
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- other: Increase in 3HTdR incorporation compared to control values.
- Test group / Remarks:
- 120, 130 and 260% was the value observed in test group
- Remarks on result:
- other: No indication of skin sensitization
- Cellular proliferation data / Observations:
- CELLULAR PROLIFERATION DATA/observation
CELLULAR PROLIFERATION DATA:
The response was expressed as radioactive disintegrations per minute per lymph node (dpm/node) and as the ratio of 3HTdR incorporation into LNC of test nodes relative to that recorded for control nodes(test/control ratio).
DETAILS ON STIMULATION INDEX CALCULATION: No data available
EC3 CALCULATION: No data available
CLINICAL OBSERVATIONS: No data available
BODY WEIGHTS: No data available
Any other information on results incl. tables
No sensitization observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- Cyclopentane, methoxy- was observed for its skin sensitizing potential. In this assays, the test/control ratios obtained for 25, 50 and 100% (as supplied) v/v concentration of Cyclopentane, methoxy- were 120, 130 and 260%, respectively, which indicate that Cyclopentane, methoxy- did not show the potential to induce skin sensitization.
- Executive summary:
Skin Sensitization of Cyclopentane, methoxy was observed in mouse by LLNA mode.The proliferative response of the lymph node cells (LNC) from the draining auricular lymph node
was assessed five days following the initial application, by measurement of the incorporation of 3H-thymidine by β-scintillation counting of LNC suspension. The response was expressed as radioactive disintegrations per minute per lymph node (dpm/node) and as the ratio of 3HTdR incorporation into LNC of test nodes relative to that recorded for control nodes(test/control ratio).TheCyclopentane, methoxy-substance is regarded as a sensitizer if at least one concentration of the chemical results in a 300% greater increase in 3HTdR incorporation compared to control values.In these assays, the test/control ratios obtained for 25, 50 and 100% (as supplied) v/v were 120, 130 and 260%, respectively, which indicate that CPME did not show the potential to induce skin sensitization. ThereforeCyclopentane, methoxy-(5614-37-9 was considered to be non sensitizing to the skin.
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