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EC number: 617-648-0 | CAS number: 849727-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-06-19 to 2003-06-20
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Non GLP study performed according to a method similar to OECD Guideline 430 and EU Method B.40. Although limited study details are given, the information is sufficient to determine the reliability.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 430 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER))
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
- Deviations:
- no
- Principles of method if other than guideline:
- The skin corrosivity potential of the test substance was assessed using the Transcutaneous Electrical Resistance Assay (TER). This involved the application of the test substance to the epidermal surface of skin discs, obtained from a humanely-killed young Wistar strain rat.
- GLP compliance:
- no
- Remarks:
- The study was conducted in a facility operating to Good Laboratory Practice within the UK national GLP monitoring programme, but the study report has not been audited by the QA unit. No formal claim of GLP compliance is made for this study.
Test material
- Reference substance name:
- 3-(2-CHLOROETHYL)-9-HYDROXY-2-METHYL-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE HYDROCHLORIDE (1:1)
- EC Number:
- 617-648-0
- Cas Number:
- 849727-62-4
- Molecular formula:
- C11H11ClN2O2.HCl
- IUPAC Name:
- 3-(2-CHLOROETHYL)-9-HYDROXY-2-METHYL-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE HYDROCHLORIDE (1:1)
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- no data
In vitro test system
- Test system:
- isolated skin discs
- Remarks:
- epidermal surface of skin discs, obtained from a humanely killed young Wistar strain rat
- Source species:
- rat
- Vehicle:
- not specified
- Details on test system:
- TEST SITE: The integrity of each pelt was confirmed using a Quality Control test. Only acceptable pelts were used to supply skin discs for use in the main study.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, removed using a jet of warm tap water
- Time after start of exposure: after 24 hour exposure
SCORING SYSTEM:
- Corrosive substances produce an irreversible loss of normal stratum corneum integrity and function; this is measured as a reduction in the inherent TER. A threshold value has been established (5 kΩ), below which materials are considered likely to be corrosive in vivo. The TER was measured using a low voltage alternating current electronic databridge. - Control samples:
- no
- Amount/concentration applied:
- TEST MATERIAL: no data
VEHICLE: no data - Duration of treatment / exposure:
- 24 hours
- Number of replicates:
- 3 skin discs
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- transcutaneous electrical resistance (in kΩ)
- Run / experiment:
- 1
- Value:
- 5.27
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Basis: mean; time point: 24 hours; standard deviation = 0.3.
- Other effects / acceptance of results:
- - The mean electrical resistance (kΩ) was 5.27 +/- 0.3. Following visual inspection, each skin disc was found to have a pale (bleached) appearance.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Although the mean electrical resistance was above the cut-off value of 5 kΩ, after visual inspection of the skin discs, the test material was considered to have the potential to be corrosive in-vivo under the conditions of the test.
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