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Diss Factsheets
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EC number: 202-809-6 | CAS number: 100-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: NTP Reproduction and Fertility Assessment using continuous breeding protocoll with evaluation of fertility of the F1 from the final litter
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study; adopted according to OECD SIDS, peer reviewed data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- SIDS Initial Assessment Report (SIAR): 1-Chloro-4-nitrobenzene CAS No: 100-00-5
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- OECD SIDS, UNEP Publications
- Title:
- No information
- Author:
- Chapin R, Gulati D, Mounce R (1997) 4-Chloronitrobenzene.|Environm Health Persp 105 [Suppl.1]: 289-290
- Bibliographic source:
- (as cited in SIDS)
- Title:
- No information
- Author:
- NTP (1991) 4-Chloronitrobenzene Reproduction and Fertility|Assessment in Swiss CD-1|mice when administered via gavage. Final Report, July, 1991
Materials and methods
- Principles of method if other than guideline:
- Method: other: NTP continuous Breeding Protocol, see also ME
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: >99 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Swiss CD-1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- Exposure period: see type and remarks
Premating exposure period (males): 7 d
Premating exposure period (females): 7 d
Duration of test: 34 weeks - Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 62.5, 125 or 250 mg/kg bw/day dissolved in corn oil
Basis:
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
open allclose all
- Dose descriptor:
- other: NOAEL(fertility)
- Effect level:
- 125 mg/kg bw/day
- Remarks on result:
- other: Generation not specified (migrated information)
- Dose descriptor:
- other: NOAEL (adult general toxicity)
- Effect level:
- 125 mg/kg bw/day
- Remarks on result:
- other: Generation not specified (migrated information)
- Dose descriptor:
- other: LOAEL (offspring general toxicity)
- Effect level:
- 62.5 mg/kg bw/day
- Remarks on result:
- other: Generation not specified (migrated information)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
F0-mice:
mortality: 3,3,1,4 control to high dose, but not evaluated
as treatment related; all groups: body weight gain
throughout the study, reduced water consumption, none of the
mice cyanotic, high dose: reduced food consumption
F0 fertility:
control, 62.5, 125 mg-pairs:
100 resp. 95 % of the pairs delivered at least four litters
250 mg-gr.: 100 % of the pairs delivered the 1rst and 93 %
the 2nd litter and only 86 % delivered the 3rd and 79 %
delivered the 4th litter, for the 2nd through the 5th
litters significant dose-dependent decreasing trend of
percent of pairs delivering, proportion of born alive of the
final litter significantly reduced;
in all groups: average number of live pups per litter was
comparable, sex ratio of pups born alive was not affected
125 mg- and 250 mg-gr.: compared to the control group dam
weights were increased at delivery of the final litter (113%
resp. 110% compared to the control) and 21 days after the
delivery of the final litter (112% resp. 118%). A trend test
was positive.
F1-pups:
none of the pups were noted as being cyanotic,
125, 250 mg-gr (male, female and combined), 62.5 mg-gr (male
and combined): reduced live pup weights at birth;
125, 250 mg-gr.: pup weights adjusted for litter size sign.
reduced, dose-related response, in the final litter of the
continuous breeding phase, the F1 weight gain was adversely
affected
250 mg-gr.: in the final litter of the continuous breeding
phase, the F1 pup survival were adversely affected,
proportion of born pups alive sign. decreased;
F1-adult (control and 250 mg-gr):
water consumption comparable, at mating most of the 250
mg/kg bw/d group F1 animals were cyanotic (eyes,skin: blue
tint, urine color: amber); fertility, mating and pregnancy
indices were comparable, number of live pups delivered by
250 mg-dosed pairs was lower than from conrol pairs, the
proportion of F2 pups born alive and live F2 pups weights at
birth were significantly reduced in the 250 mg-group;
sperm parameters and vaginal cytology (F1, contr. and 250
mg-gr.):
the average estrous cycle length in the F1 females was
significantly increased whereas epididymal sperm motility,
sperm count and sperm morphology were not affected in the
F1 males by 4-chloronitrobenzene treatment;
gross pathology, F1, 250 mg-gr.:
in both F1 sexes: at terminal sacrifice, absolute liver
weight and liver-to-body weight ratios were increased and
spleens were extremely enlarged and darkened while body
weights were unchanged;
in males, absolute seminal vesicle weights were
significantly decreased and seminal vesicle-to-body weight
ratios were similarly affected at 250 mg/kg bw/d;
there was no evidence of an androgen deficiency lesion in
the testes of 5 high-dose males examined
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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