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Diss Factsheets
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EC number: 700-372-0 | CAS number: 1128026-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted at a GLP-accredited testing facility
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Pre-study solubility work indicated that it was not possible to obtain a testable solution of the test material using traditional methods (e.g. ultrasonication, high-shear mixing). The test material is poorly water soluble and known to rapidly degrade in water to give t-butyldimethylsilanol and 3-(trimethoxymethylsilyl)-propane-1-thiol. Due to the volatility of 3-(trimethoxymethylsilyl)-propane-1-thiol, chemical analysis of the test preparations was conducted for t-butyldimethylsilanol alone.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Nominal concentrations of 6.25, 12.5, 25, 50, and 100% v/v saturated solution
Samples taken at 0h and 72h for analysis
Concentrations of t-butyldimethylsilanol at 0h were 5.7, 12, 24, 47, and 96mg/l respectively. At 72h, these had reduced to 0.854, 1.61, 1.72, 4.69, and 6.83mg/l respectively.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Test solutions were prepared by stirring 500mg of test material in 1l culture medium at approximately 7500rpm for 30 minutes. Undissolved test material was removed via filtration through a 0.2µm Sartorius Sartopore filter, with the initial 500ml being discarded to precondition the filter. A sample was immediately taken for chemical analysis. The saturated solution was serially diluted to prepare the remainder of the test series.
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- Strain: CCAP 276/20.
Liquid cultures of the test organism were obtained from the Culture Collection of Algae and Protazoa (CCAP), Dunstaffnage Marine Laboratory, Oban, Argyll, Scotland.
Master cultures were maintained in the laboratory by the periodic replenishment of the culture medium.
The master cultures were maintained in the laboratory under constant aeration and constant illumination at 21±1°C.
Master culture was added to approximately 100ml of culture media in conical flasks to give an initial cell density of 10³/ml. The flasks were plugged with polyurethane foam stoppers and kept under constant agitation by orbital shaker (100-150rpm) and constant illumination at 24±1°C until the cell density was approximately 10-100x10³/ml.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Post exposure observation period:
- none
Test conditions
- Test temperature:
- 24±1°C
- pH:
- 7.1-7.7 (0h), 7.5-7.8 (72h)
- Nominal and measured concentrations:
- Nominal concentrations: 6.25, 12.5, 25, 50, and 100%
Measured concentrations of t-butyldimethylsilanol at 0h were 5.7, 12, 24, 47, and 96mg/l respectively. At 72h, these had reduced to 0.854, 1.61, 1.72, 4.69, and 6.83mg/l respectively. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 other: %
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 other: %
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- cell number
- Results with reference substance (positive control):
- EC50 (growth rate 0-72h) = 0.52mg/l (95% CL 0.43-0.62mg/l)
EC50 (yield 0-72h) = 0.29mg/l (95% CL 0.25-0.33mg/l)
Applicant's summary and conclusion
- Conclusions:
- The test material did not impair the growth of algae up to the highest concentration tested, equivalent to 96mg/l t-butyldimethylsilanol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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