o-anisic acid

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Qualifier:

according to guideline

Guideline:

other: modelling database

Principles of method if other than guideline:

The aquatic toxicity - Median Lethal Concentration (LC50, mg/L) (v5.0.0.184).The aquatic toxicity module provides the concentration of the test substance in water predicted to be lethal to 50% of the exposed individuals (LC50, mg/L) of the species Fathead minnow (Pimephales promelas). Each LC50 calculation is supported by estimated Reliability Index (RI) which allows evaluation of the quality of predictions and the applicability domain of a corresponding model.

GLP compliance:

no

Specific details on test material used for the study:

- Name of test material: 2-methoxybenzoic acid (2-MBA)
- Molecular formula: C8H8O3
- Molecular weight: 152.1482 g/mol
- Smiles notation: COc1ccccc1C(=O)O
- InChl:1S/C8H8O3/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5H,1H3,(H,9,10)
- Substance type: Organic
- Physical state: Solid

Analytical monitoring:

no

Vehicle:

not specified

Test organisms (species):

Pimephales promelas

Details on test organisms:

TEST ORGANISM
- Common name: Fathead minnow

Test type:

not specified

Water media type:

not specified

Total exposure duration:

96 h

Remarks on exposure duration:

No details

Reference substance (positive control):

not specified

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

360 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

not specified

Conclusions:

From ACD (Advanced Chemistry Development)/I-Lab predictive module (v5.0.0.184) the predicted Median Lethal Concentration (LC50, mg/L) for fish species Pimephales promelas of the test substance determined to be 360 mg/l on the basis of mortality effects.

Executive summary:

According to aquatic toxicity module i.eACD/LabsI-Lab 2.0; Algorithm Version: v5.0.0.184 the lethal concentration (LC50) of the test substance 2-methoxybenzoic acid was predicted to be 360 mg/l on fish species Fathead minnow (Pimephales promelas). The reliability Index (RI) of the LC50 calculation for 2-methylanthraquinone was 0.57(As per model substance have moderate and high reliability if RI > 0.5). Thus reported RII value indicate it has moderate reliability. The LC50 value indicates that the 2-methoxybenzoic acid considered as non-toxic to fish and thus can be considered to be not classified as per the CLP criteria.

Description of key information

According to aquatic toxicity module i.eACD/LabsI-Lab 2.0; Algorithm Version: v5.0.0.184 the lethal concentration (LC50) of the test substance 2-methoxybenzoic acid was predicted to be 360 mg/l on fish species Fathead minnow (Pimephales promelas). The reliability Index (RI) of the LC50 calculation for 2-methylanthraquinone was 0.57(As per model substance have moderate and high reliability if RI > 0.5). Thus reported RII value indicate it has moderate reliability. The LC50 value indicates that the 2-methoxybenzoic acid considered as non-toxic to fish and thus can be considered to be not classified as per the CLP criteria.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

360 mg/L

Additional information

Short term toxicity to fish was summarized with 2 predicted data are as follows:

According to aquatic toxicity module i.eACD/LabsI-Lab 2.0; Algorithm Version: v5.0.0.184 the lethal concentration (LC50) of the test substance 2-methoxybenzoic acid was predicted to be 360 mg/l on fish species Fathead minnow (Pimephales promelas). The reliability Index (RI) of the LC50 calculation for 2-methylanthraquinone was 0.57(As per model substance have moderate and high reliability if RI > 0.5). Thus reported RII value indicate it has moderate reliability. The LC50 value indicates that the 2-methoxybenzoic acid considered as non-toxic to fish and thus can be considered to be not classified as per the CLP criteria.

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for test substance  2-methoxybenzoic acid (CAS: 579-75-9) on the basis of effects observed in a static freshwater system. The lethal concentration LC50 value for the substance was estimated to be 2783.679 mg/l for fish for 96 hr duration. Based on this value it can be concluded that the 2-methoxybenzoic acid can be considered to be non-toxic to aquatic environment and can be considered as not classified as per the CLP classification criteria.

Based on the predicted data from ACD labs and ECOSAR version 1.11, the toxicity to fish was predicted and based on the values, 2-methoxybenzoic acid (CAS: 579-75-9) was considered to be non-toxic to fish and can be considered to be not classified as per the CLP regulations.