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EC number: 234-421-8 | CAS number: 12003-13-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- In the acute dermal toxicity study, serious corrosive effect was observed.
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Justification for type of information:
- This study was carried out by Japanese government to confirm its toxicity.
- Qualifier:
- no guideline available
- Version / remarks:
- The study was carried out refer to OECD guideline, but guideline number was not specified.
- Principles of method if other than guideline:
- Similar to OECD 434
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Specific details on test material used for the study:
- Titanium trichloride is unstable substance and gradually decomposes at room temperature. Thus, the solution prepared by dissolving titanium in the hydrochloric acid solution was used as test material.
This solution was dark violet liquid and its density was 1.28 g/ml. the concentration was over 20%. - Species:
- rat
- Strain:
- Wistar
- Remarks:
- Slc
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Japan SLC
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 11 week
- Weight at study initiation: Not known
- Fasting period before study:
- Housing:Metal cage (w 220 x D 220 x H170 mm)
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation period:1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24±1
- Humidity (%): 55 ± 5
- Air changes (per hr): 18
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hours light - Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal area of the body
- % coverage: approximately 10%
- Type of wrap if used: The test solution was spread on the lint cloth and be hold on the dorsal skin. The cloth was covered with aluminum foil and fixed with Tegaderm transparent dressing tape(Sumitomo 3M). In addition that, the trunk of the animal was swathed with Reston self-adhering foam pads (Sumitomo 3M) and Silkytex adhesive bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit):2000 mg/kg as 20% titanium trichloride solution.
- Concentration (if solution): 20, 50 and 100 %
- Constant volume or concentration used: yes; constant concentration
- For solids, paste formed: no
VEHICLE
- Amount(s) applied (volume or weight with unit): not known.
- Concentration (if solution):25, 50 and 100%
- Lot/batch no. (if required): not available
- Purity:not known - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3 rats per sex and dose.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:not known
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: - Statistics:
- not used
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks:
- as 20 % solution
- Mortality:
- No
- Clinical signs:
- No abnormal signs were observed during exposure period.
- Body weight:
- Not known
- Gross pathology:
- Necropsy of all animals on 14th day was carried out. MIcroscopic examination of organs did not show any change.
- Other findings:
- Observation of skin after removal of the lint cloth, which contained test chemical.
The skin of contact area was seriously corroded and the skin was adhered on the lint cloth and bled for both male and female animals.
After 2nd day, the corroded skin turned to black and began eschar formation. After 5th day, the eschar began to desquamate from the edge of the eschar, but did not disappear even on the 14th day. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal toxicity study on titanium trichloride was conducted using 20% hydrochloric acid solution of titanium trichloride.
This solution showed serious skin corrosion, but no mortality was observed even in the dosage 2000 mg/kg. Thus LD50 was estimated over 2000mg/kg as 20 % solution. - Executive summary:
The acute dermal toxicity study on titanium trichloride was conducted using 20% hydrochloric acid solution of titanium trichloride. This solution showed serious skin corrosion, but no mortality was observed even in the dosage 2000 mg/kg. Thus LD50 was estimated over 2000mg/kg as 20 % solution.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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