Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-974-6 | CAS number: 16919-73-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The administration and the pre- and post- observation periods were between 27 June and 09 August 1989.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, conducted to OECD guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Remarks:
- No significant deviations
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reference substance 003
- Cas Number:
- 16919-73-6
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Potassium hexachloropalladate (IV)
- Substance type: Red powder
- Physical state: Solid
- Analytical purity: 26.8% Pd
- Purity test date: Apparently 07 July 1989
- Lot/batch No.: 041368
- Expiration date of the lot/batch: no data
- Stability under test conditions: Stable
- Storage condition of test material: Kept desiccated in a closed container in a fridge
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Bor: WISW (SPFCpb)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann Versuchstierzucht GmbH & Co. KG., D-4799 Borchen
- Age at study initiation: 8 weeks (males); 9 weeks (females)
- Weight at study initiation: 152-210 g (males); 136-167 g (females)
- Fasting period before study: 16 hours
- Housing: 1 rat/cage in type II Macrolon cages
- Diet (e.g. ad libitum): ad libitum standard diet ssniff R “Special diet for rats”, supplied by ssniff Spezialfutter GmbH, D-4770 Soest
- Water (e.g. ad libitum): ad libitum from Stadtwerke Beilefeld (Municipal Works)
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5-22.5
- Humidity (%): 40-70
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12/12 (6 am- 6 pm: artificial lighting; 6 pm-6 am: “natural light-dark-rhythm”)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Details on oral exposure:
VEHICLE
- Concentration in vehicle: 46.4, 68.1 or 100 mg/ml.
- Amount of vehicle (if gavage): 21.5 ml
- Justification for choice of vehicle: no data
- Lot/batch no. (if required): Batch 5479, supplied by H. Lamotte, D-2800 Bremen
- Purity: no data- Doses:
- Rats were administered 1000, 1470 or 2150 mg/kg bw in 21.5 ml/kg bw.
- No. of animals per sex per dose:
- Five rats/sex/dose
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days (a single animal was observed for 21 days because of reduced body weight at 14 days)
- Frequency of observations and weighing: Observed for 4-6 hours after administration, then once daily; weighed at the beginning and at 7 and 14 days (or after death; a single animal was weighed at 21 days); deaths recorded twice daily, except on Saturdays, Sundays and national holidays when they were only counted once.
- Necropsy of survivors performed: yes
- Other examinations performed: external appearance, “body orifices”, thoracic and abdominal body cavities and their contents, histopathology of the lungs, clinical signs, body weight.- Statistics:
- Acute oral median lethal dose (LD50)
Results and discussion
- Preliminary study:
- Not applicable
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 448 mg/kg bw
- 95% CL:
- > 1 234 - < 1 696
- Remarks on result:
- other: Probit analysis
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 358 mg/kg bw
- 95% CL:
- > 924 - < 1 882
- Remarks on result:
- other: Probit analysis
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 562 mg/kg bw
- 95% CL:
- > 1 123 - < 2 249
- Remarks on result:
- other: Probit analysis
- Mortality:
- Two males in the mid-dose group died 6 days after administration; all high-dose males died within 7 days. Four females in the mid-dose group died within five days of administration; all high-dose females died within 3 days.
- Clinical signs:
- Slightly reduced movement, diarrhoea, red nasal discharge and “sunken sides” were seen in some of the females given 1000 mg/kg bw. At 1470 and 2150 mg/kg bw, more obvious signs of neurotoxicity than reduced movement were reported (restrained gait, tremor, reduced muscle tone), along with other general signs of toxicity (including piloerection, strenuous respiration yellow nasal discharge and, in the high dose group only, red-discoloured urine). In males, slightly reduced movement was reported in two animals given 1000 mg/kg bw. Higher doses caused similar neurotoxic and general toxicity symptoms as those seen in females (but included loss of righting reflex, reduced body temperature and black discolouration of the faeces).
- Body weight:
- Reduced body weight gain was reported in three females given 1000 mg/kg bw, and in one female and two males given 1470 mg/kg bw.
- Gross pathology:
- Effects on the digestive organs (glandular stomach, forestomach, intestine and liver) consistent with a local irritant effect were reported in mid- and high-dose males and females. A slightly diminished spleen was noted in one mid-dose male, and one mid-dose female exhibited a foam-filled trachea. Abnormalities in the lungs (dark red, puffy, emphysematous appearance and dark red discolouration or spotting) were seen in high-dose male and female animals; dark red spotting in the lungs was also seen in mid-dose females.
- Other findings:
- - Histopathology: Lung congestion was reported in males given 2150 mg/kg bw and in females given 1470 and 2150 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a GLP study, conducted according to OECD guidelines, the acute oral LD50 of dipotassium hexachloropalladate in the rat has been calculated as approximately 1400 mg/kg bw.
- Executive summary:
In a GLP study conducted according to OECD Test Guideline 401, five rats/sex/group were treated with 1000, 1470 or 2150 mg/kg bw dipotassium hexachloropalladate by stomach tube, and observed for 14 days (although one animal was observed for 21 days).
Two males and four females in the mid-dose group died within six days; all animals in the high-dose group died within seven days. Toxic effects included neurotoxicity, local irritant effects on the digestive organs and lung damage.
Based on the results of this study, dipotassium hexachloropalladate should be classified for acute oral toxicity (category 4) according to EU CLP criteria (EU 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.