Palladium (II) di(4-oxopent-2-en-2-oate)

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: This is a guideline experimental study, of unknown GLP status, minor restirictions in the design and/or reporting but otherwise accepatable for assessment.

Qualifier:

according to guideline

Guideline:

other: ISO 9277:2010(E)

Qualifier:

according to guideline

Guideline:

other: AA_LP_814_BET_08

Qualifier:

according to guideline

Guideline:

other: ISO 14488:2007(E)

Qualifier:

according to guideline

Guideline:

other: ISO 13320:2009(E)

Qualifier:

according to guideline

Guideline:

other: SAA_Troken_DISP, SAA LB2000

GLP compliance:

not specified

Type of method:

Laser scattering/diffraction

Type of distribution:

other: dry dispersion

Percentile:

D50

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Percentile:

D10

Mean:

0.66 µm

Remarks on result:

other: Range; 0.64 - 0.67 µm

Percentile:

D50

Mean:

2.1 µm

Remarks on result:

other: Range; 2.1 µm

Percentile:

D90

Mean:

5.4 µm

Remarks on result:

other: Range; 5.4 - 5.5 µm

Mean specific surface area N-BET = 2.63  ± 0.03 m²/g. Range; 2.61  ±0.01 m²/g to 2.65  ±0.01 m²/g

Table 1: N-BET analysis data and percentiles calculated from the particle size distribution for palladium

	Analysis 1	Analysis 2	Analysis 3	Average
Specific surface area N-BET (m^2/g)	2.65  ±0.01	2.61  ±0.01		2.63  ±0.03
X10;3 (μm)	0.64	0.66	0.67	0.66
X50;3 (μm)	2.1	2.1	2.1	2.1
X90;3 (μm)	5.5	5.4	5.4	5.4

Conclusions:

The average 10th, 50th and 90th percentile particle sizes for bis(acetylacetonato) palladium (II) were 0.66, 2.1 and 5.4 μm, respectively. The average specific surface area was determined as 2.63 ± 0.03 m2/g.

Executive summary:

This is a guideline experimental study, of unknown GLP status, minor restrictions in the design and/or reporting but otherwise acceptable as the key study for this endpoint. The average 10th, 50th and 90th percentile particle sizes for bis(acetylacetonato) palladium (II) were 0.66, 2.1 and 5.4 μm, respectively. The average specific surface area was determined as 2.63 ± 0.03 m2/g.

Reference 2

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

28 September 2010 to 13 December 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP complaint, guideline study, available as unpublished report acceptable without restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Version / remarks:

Screening Test

Principles of method if other than guideline:

The method used is based on a procedure designed to comply with that given in 'Particle size distribution, fibre length and diameter distribution', June 1996 European Commission technical guidance document, which satisfies the requirements of OECD Guideline 110.

GLP compliance:

yes (incl. QA statement)

Type of method:

sieving

No.:

#1

Size:

< 100 µm

Distribution:

13.1 %

The results of the sieving procedure are shown below:

Measurement	Result
Mass of test item transferred to sieve	10.04g
Mass of test item passed through sieve	1.32g
Proportion of test item <100µm	13.1%

Conclusions:

In an OECD 110 Granulometry (Screening Test) the proportion of Palladium (II) di(4-oxopent-2-en-2-oate) <100 μm was 13.1%

Executive summary:

This is a GLP compliant, guideline study considered suitable for use as the key study for this endpoint. Palladium (II) di(4-oxopent-2-en-2-oate) < 100 μm was 13.1%

Description of key information

The average 10th, 50th and 90th percentile particle sizes for palladium (II) di(4-oxopent-2-en-2-oate) were 0.66, 2.1 and 5.4 μm, respectively. The average specific surface area was determined as 2.63 ± 0.03 m2/g.

Additional information

Potthoff (2012) is a non-GLP, guideline experimental study and is considered suitable for use as the key study for this endpoint. The average 10th, 50th and 90th percentile particle sizes for palladium (II) di(4-oxopent-2-en-2-oate) were 0.66, 2.1 and 5.4 μm, respectively. The average specific surface area was determined as 2.63 ± 0.03 m2/g.

Walker and White (2011) is a GLP compliant, guideline study and provides screening information for this endpoint. The proportion of palladium (II) di(4-oxopent-2-en-2-oate) < 100 μm was 13.1%.

The dustiness of palladium di(4-oxopent-2-en-2-oate) was tested in a modified Heubach procedure according to the guideline DIN 55992-1:2006 (Selck and Parr 2011). The study is non-GLP, but follows a standard guideline and is considered to be reliable. The total dustiness of palladium di(4-oxopent-2-en-2-oate) was determined to be 232.05 mg/g. The inhalable fraction was 137.54 mg/g, the thoracic fraction was 29.84 mg/g and the respirable fraction was 15.44 mg/g. The Mass Median Aerodynamic Diameter (MMAD) was 38.17 μm with Geometric Standard Deviation of 2.53 μm.