Registration Dossier
Registration Dossier
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EC number: 271-816-4 | CAS number: 68609-04-1 The complex combination of hydrocarbons produced by the distillation of products from the air oxidation of cyclohexane after removal of acidic materials. It consists of hydrocarbons having carbon numbers predominantly in the range of C6 through C12 and boiling in the range of approximately 172°C to 324°C (342°F to 615°F).
Endpoint summary
Administrative data
Description of key information
Irreversible scaling was observed in a valid skin irritation study.
Mild, reversible corneal was observed in a valid eye irritation study.
Key value for chemical safety assessment
Additional information
Skin irritation:
In a skin irritation assay with rabbits 0.5 ml of the test substance was applied on the clipped back of 3 animals for 4h (BASF AG, 1987). Skin effects were observed for 8 days.
Reversible erythema was observed within 24 h after exposure, however scaling was still present at the end of the observation period.
Eye irritation:
In an eye irritation assay with rabbits 0.1 ml undiluted test substance was applied into the conjunctival sac of 3 animals. The eye was kept unwashed and was observed for 8 days.
Mild, reversible corneal opacity was observed.
Justification for classification or non-classification
Based on irreversible scaling the test substance is classified as skin irritant according to EU (R38) and GHS (Cat. 2).
Since the mean (24, 48, 72h) of the cornea scores was <2, of the iris scores <1, of the conjunctivae scores <2.5 and of the chemosis scores <2 no classification according to Directive 67/548 EU is warranted. Due to the corneal score (means 24, 48, 72h) of 1, which was reversible within the 8 day observation period, cat2B according to CLP Directive 1272/2008 is indicated.
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