Registration Dossier
Registration Dossier
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EC number: 237-249-1 | CAS number: 13708-85-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04/1995
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Disodium phosphonate
- EC Number:
- 237-249-1
- EC Name:
- Disodium phosphonate
- Cas Number:
- 13708-85-5
- Molecular formula:
- Na2HPO3
- IUPAC Name:
- disodium phosphonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Zucht Winkelmann, Paderborn
- Age at study initiation: adult
- Weight at study initiation: 200 g (females), 220 g (males9
- Housing: single cages
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 °C ± 2 °C
- Humidity (%): 50 - 60 %
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: tylose
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20 - 30 %
- Amount of vehicle (if gavage): 1.0 - 1.7 ml/100 g bw - Doses:
- 2,000 mg/kg bw
3,000 mg/kg bw
4,000 mg/kg bw
5,000 mg/kg bw - No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 24 h, 7 d, 14 d
- Necropsy of survivors performed: yes
- Other examinations performed: macroscopic histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2,000 mg/kg bw (0/6)
3,000 mg/kg bw (0/6)
4,000 mg/kg bw (2/6)
5,000 mg/kg bw (6/6) - Clinical signs:
- other: 4,000 mg/kg bw: delayed reactivity
- Gross pathology:
- no effects related to the substance
- Other findings:
- - Organ weights: normal
- Histopathology: no findings
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: FDA 1959, OECD 401 (1981)
- Conclusions:
- The LD50 was deteremined to be 4,000 mg/kg bw; therefore the substance can be considered as practically non-toxic.
- Executive summary:
The LD50 was deteremined to be 4,000 mg/kg bw; therefore the substance can be considered as practically non-toxic.
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