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EC number: 206-277-6 | CAS number: 320-51-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
No internal genotoxicity studies were conducted with 5-Amino-2-chlorobenzotrifluoride.
Results of a genotoxicity studies with 5-Amino-2-chlorobenzotrifluoride were published in literature:
5-Amino-2-chlorobenzotrifluoride showed no DNA damaging activity in a Bacillus subtilis Rec-Assay (B. subtilis parental strain PB 1652 (trpC2 metB10 lys3) and repair deficient mutant PB 1791 (trpC2 metB10 recE4)) when tested at doses of 500, 1000 and 5000 µg/disk.
5-Amino-2-chlorobenzotrifluoride did not show a mutagenic potential in a bacterial reverse mutation assay (Ames test in S. typhimurium strains TA 1535, TA 1537, TA 1538, TA 98 and TA 100) when tested at non toxic concentrations of 50, 100 and 500 µg/plate in the absence or presence of metabolic activation (S9 mix) by direct plate incorporation and by preincubation (only TA 100).
Moreover, 5-Amino-2-chlorobenzotrifluoride showed no potential to induce mitotic crossing-over (reciprocal recombination) or mitotic gene conversion (non reciprocal recombination) in a test with S. cerevisiae strain 6117 at a concentration of 125 µg/ml in the absence and presence of metabolic activation .
According to current guidelines the above discussed publication has some limitations (e.g. Ames-Test: only three instead of five concentrations tested , negative results were not verified in a second test and it was not explained why, no testingwas conductedwith S. typhimurium strain TA 102) but taken all results together there is no evidence of a mutagenic potential of 5 -Amino-2 -chlorobenzotrifluoridein vitro.
Short description of key information:
No internal genotoxicity studies were conducted with 5-Amino-2-chlorobenzotrifluoride.
Results of a genotoxicity study with 5-Amino-2-chlorobenzotrifluoride were found in the literature (May 2011):
Rec-Assay (Bacillus subtilis); dosages 500-5000 µg/disk: negative
(Mazza, G. et al. (1986); Il Farmaco Edizione Pratica v. 41, ISS 7, p. 215-225)
Bacterial reverse mutation assay (Ames test); dosages 50-500 µg/plate with and without S9 mix: negative
(Mazza, G. et al. (1986); Il Farmaco Edizione Pratica v. 41, ISS 7, p. 215-225)
Gene conversion and mitotic crossing-over (Saccharomyces cerevisiae); dosage 125 µg/ml with and without S9-mix: negative
(Mazza, G. et al. (1986); Il Farmaco Edizione Pratica v. 41, ISS 7, p. 215-225)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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