2(1H)-Pyridinone, 4-amino-5-methyl-

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-03-21 to 2018-05-24

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

GLP compliance:

no

Type of method:

capillary method

Test material

Test material information

Constituent 1

Reference substance name:

4-amino-5-methyl-1,2-dihydropyridin-2-one

EC Number:

682-818-3

Cas Number:

95306-64-2

Molecular formula:

C6 H8 N2 O

IUPAC Name:

4-amino-5-methyl-1,2-dihydropyridin-2-one

Test material form:

solid

Results and discussion

Melting / freezing point

Key result

Melting / freezing pt.:

>= 292.2 - <= 304 °C

Atm. press.:

1 013.25 hPa

Decomposition:

ambiguous

Remarks:

At 304.0 °C the liquefying point, a complete meniscus is formed at the surface, but an appreciable amount of the sample remains solid, was visual observed. At the end of the test the test item was liquid and black.

Decomp. temp.:

304 °C

Sublimation:

no

Any other information on results incl. tables

The determination of the melting point was performed by visual judgement using the capillary method. In the preliminary tests the test item starts melting at 310 °C. The test item showed four stages of melting. The melting started at 292.2 °C (stage A: Beginning of melting / wet point: Fine droplets adhere uniformly on the inside wall of the capillary tube.) At 304.0 °C the last stage D of melting (Liquefying point: A complete meniscus is formed at the surface, but an appreciable amount of the sample remains solid.) was visual observed. At the end of the test the test item was liquid and black; it is assumed that the test item decomposed at 304°C.

Applicant's summary and conclusion

Conclusions:

4-Amino-5-methylpyridinon melted in the range of 292.2 °C to 304.0 °C (565.4 K to 577.2 K).

Executive summary:

Title:

4-Amino-5-methylpyridinon: Determination of the Melting Point / Melting Range

Purpose:

The purpose of this study was to evaluate the melting point or melting range of 4-Amino-5-methylpyridinon by the capillary method using an electronic controlled heating system.

This study was based on the procedures indicated by the following internationally accepted methods:

Commission Regulation (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) (originally published as Council Regulation (EC) No 440/2008, corrigendum according to Official Journal of the European Union (EN) dated June 3, 2008, L 143/55), Annex V, Part A, A.1.: “Melting /Freezing Temperature”, Official Journal of the European Union, L 142, Volume 51, 31 May 2008

Organization for Economic Co-operation and Development (OECD), Guidelines for Testing of Chemicals, Guideline No.: 102, “Melting Point/Melting Range”, adopted July 27, 1995

Product Properties Test Guideline of the United States Environment Protection Agency (EPA), OPPTS 830.7200 Melting Point / Melting Range, March 1998

Results: 

The determination of the melting point was performed by visual judgement using the capillary method. In the preliminary tests the test item starts melting at 310 °C. The test item showed four stages of melting. The melting started at 292.2 °C (stage A: Beginning of melting / wet point: Fine droplets adhere uniformly on the inside wall of the capillary tube.) At 304.0 °C the last stage D of melting (Liquefying point : A complete meniscus is formed at the surface, but an appreciable amount of the sample remains solid.) was visual observed. At the end of the test the test item was liquid and black; it is assumed that the test item decomposed at 304°C. This study is classified acceptable and satisfies the guideline requirements for melting point studies.