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EC number: 220-985-2 | CAS number: 2958-36-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 Nov - 20 Dec 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-amino-2',5-dichlorobenzophenone
- EC Number:
- 220-985-2
- EC Name:
- 2-amino-2',5-dichlorobenzophenone
- Cas Number:
- 2958-36-3
- Molecular formula:
- C13H9Cl2NO
- IUPAC Name:
- 4-chloro-2-(2-chlorobenzoyl)aniline
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- - Age at study initiation: no data
- Weight at study initiation: males 2659-3056 g
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.5 - 20°C
- Humidity (%): 35 - 50%
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- other: 0.5 % (m/v) solution of Tylose MH 1000 in deionised water
- Controls:
- other: Approximately 24 hours before testing the fur on the backs of the animals was closely clipped over an area of approximately 4 x 5 cm on the left and right side of the spine. One area was used as control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 g
VEHICLE
- Amount(s) applied: 0.5 ml of a 0.5 % (m/v) solution of Tylose MH 1000 in deionised water - Duration of treatment / exposure:
- Animal 1: 3 min, 1 and 4 h
Animals 2 and 3: 4 h - Observation period:
- 1, 24 48 and 72 h after patch removal
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: ca. 6 cm2
- Type of wrap if used: gaze patch
REMOVAL OF TEST SUBSTANCE
- Washing: cleaned with deionised water without altering the integrity of the epidermis
- Time after start of exposure: 4h
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, 2 and 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal: #1 and 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritant / corrosive response data:
- Animal 1: very slight erythema and very slight edema were observed at 1 h grading following 3 min and 1 h treatment. Very slight edema was observed at 1 h grading after 4 h treatment.
Animal 2: very slight edema was observed at the 1 and 24 h gradings following 4 h treament. At the 48 h grading, the skin reaction had fully reversed.
Animal 3: very slight edema was observed at the 1 h grading following 4 h treament. - Other effects:
- No further local or systemic effects were noted.
Any other information on results incl. tables
Animal No: | Exposureperiod | Observed grades of skin alterations at each observation time | |||||||
Erythema hours after administration | Oedema hours after administration | ||||||||
1 | 24 | 48 | 72 | 1 | 24 | 48 | 72 | ||
1 | 3 min | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
1h | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | |
4h | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | |
Control | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
2 | 4h | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Control | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
3 | 4h | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Control | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In accordance with the results of this study and in accordance with the criteria of Regulation /EC) 1272/2008, ADB may be classified as a substance that is non-irritant to the skin.
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