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Diss Factsheets
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EC number: 440-240-7 | CAS number: 1282554-35-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-10-18 to 2011-11-01
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods (China) with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The Guidelines for the Testing of Chemicals (State Environmental Protection Administration of China, 2004, 5) and The Guidelines for the Hazard Evaluation of New Chemical Substances (State Environmental Protection Administration of China, 2004, 6)
- Principles of method if other than guideline:
- limit test, similar to OECD 403; groups of animals are exposed to a limit concentration (limit test) for a predetermined duration of 4 hours in oder to determine a LC50 value.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
- IUPAC Name:
- 2-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- the sample was milled by a micro-mill and stored in a desiccator for generating test dust
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Vital River Lab Animal Technology Co., Ltd., - Age at study initiation: no data- Weight at study initiation: 180 -220g- Housing: individual- Diet (e.g. ad libitum): ad libitum (except during exposure); Beijing Keao Xieli Laboratory Diet Co. Certificate No. SCXK (Jing) 2009-0012)- Water (e.g. ad libitum): ad libitum (except during exposure)- Acclimation period: no dataENVIRONMENTAL CONDITIONS: kept in individual ventilated cages
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION- Exposure apparatus/Method of holding animals in test chamber: Nose-only exposure chamber, constructed as individual plastic rat holders which were positioned in two tiers around the outsides, so that only the noses of the rats were exposed to the generated dust.- System of generating particulates/aerosols: dust generator- Method of particle size determination: not determinedTEST ATMOSPHERE- Brief description of analytical method used: Five gravimetric samples of chamber atmosphere were drawn from the breathing zone of the rats during exposure at about 60-minutes intervals through a filter cassette holding a pre-weighed CPVC fiber filter by a SIBATA air sampler (calibrated by a foam-film flowmeter). The sampling flow rate was 10 L/min and the sampling duration was 15 seconds. The CPVC fiber filters were placed in a desiccator for 24 hours and then weighed before sampling. They were reweighed by the same manner 30 minutes after sampling. The concentration of the test substance was accounted from the mass on the filter. The calculation formula of concentration was as follows:C(mg/m3) = weight of filter post-sampling (g) – weight pre-sampling (g)/sample volume (L) x 10^6- Samples taken from breathing zone: yes
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5496+-613 mg/m3 or 5.496 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days- Frequency of observations and weighing: daily; bodyweight were measured on day 3, 7, 14- Necropsy of survivors performed: yes- Other examinations performed: mortality and clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 496 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- no mortality
- Clinical signs:
- other: no toxic signs
- Body weight:
- the weights of rats were increasing during the test period
- Gross pathology:
- no gross patholgical changes
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is considered to be non-toxic under these test conditions.
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