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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 02-29, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Test material form:
- solid: particulate/powder
- Details on test material:
- Batch No.: UGe-RS Kilo 1
Color: Yellow
Odor: Not specific
Storage conditions: room temperature
Solubility and stability: Very good solubility in water, stable in solution at least 2 days
Expiring date: 12.12.2018
Correction factor: 1.07
Constituent 1
- Specific details on test material used for the study:
- Test Item name: Yellow LF 6911
Batch No.: UGe-RS Kilo 1
Appearance: Yellow powder
Purity: 93.3 % (organic part excluding water and salts not containing similar chromophore)
Solubility and stability: Very good solubility in water, stable in solution at least 2 days
Expiry date: 12 December 2018
Storage: Room temperature
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- For determination of the test item concentrations, samples were taken from each concentration level and control at the start and at the end of the test. Concentrations were determined using reverse phase HPLC method with VIS detection.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test solutions used in the test were prepared by mechanical dispersion. A stock solution was first prepared by dissolving an amount of 0.08 g test item in 800 mL dilution water (OECD medium) resulting a nominal concentration of 100 mg/L. The test solutions of subsequent lower test concentrations were prepared by appropriate diluting of this stock solution (see Table 2). The test solutions were prepared just before introduction of algae (start of the experiment).
Preparation of the test solutions:
Nominal concentration [mg/L] Stock Solution [mL] OECD Medium [mL]
100 400 –
50 200 q.s. ad 400
25 100 q.s. ad 400
12.5 50 q.s. ad 400
6.25 25 q.s. ad 400
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- Species: Raphidocelis subcapitata (formerly known as Pseudokirchneriella subcapitata)
Strain number: 61.81 SAG (identical strains: CCAP 278/4; UTEX 1648; ATCC 22662)
Origin: The algae were supplied by the SAG: Collection of Algal Cultures, D-37073 Göttingen, Germany
Breeding Conditions: The stock cultures are small algal cultures that are planted on agar regularly. These are transferred to fresh medium at least once every two months under standardized conditions according to the test guidelines.
Pre-culturing: The pre-culture is intended to give an amount of algae suitable for the inoculation of test cultures. The pre-culture was prepared with Algal Mineral Salts Culture Medium, incubated under the conditions of the test and used when still exponentially growing, normally after an incubation period of about four days. (The preculture was incubated for four days at this test.) The algal cultures used in this study did not contain deformed or abnormal cells.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Remarks:
- Reconstituted algal growth medium (OECD medium, according to OECD 201)
- Limit test:
- yes
- Total exposure duration:
- 72 h
Test conditions
- Hardness:
- Reconstituted algal growth medium (OECD medium, according to OECD 201) was used as dilution water in the experiment.
- Test temperature:
- The temperature was between 21.7 and 21.9°C measured in the flask and in the range of
21.6 – 22.5°C measured within the climate chamber. - pH:
- The pH was measured in each test group at the start (before test solutions had been distributed into the test vessels) and in each test vessel at the end of the test. The pH of the control medium was not increased by more than 1.5 units during the test. The range of the pH was 7.57 – 8.42 during the experiment.
- Dissolved oxygen:
- N/A
- Salinity:
- Stock solution Substance Final concentration in the prepared growth medium
NH4Cl 1 5.0 mg/L
Stock solution 1 MgCl2 5.6 mg/L*
(macro nutrients) CaCl2 × 2 H2O 18.0 mg/L
MgSO4 × 7 H2O 15.0 mg/L
KH2PO4 1.6 mg/L
Stock solution 2 FeCl3 × 6 H2O 64.0 µg/L
(iron) Na2EDTA × 2H2O 100.0 µg/L
Stock solution 3
(trace elements) H3BO3 185.0 µg/L
MnCl2 × 4 H2O 415.0 µg/L
ZnCl2 3.0 µg/L
CoCl2 × 6 H2O 1.5 µg/L
CuCl2 × 2 H2O 0.01 µg/L
Na2MoO4 × 2 H2O 7.0 µg/L
Stock solution 4
(bicarbonate) NaHCO3 50.0 mg/L
* This corresponds to the concentration of 12.0 mg/L of MgCl2 × 6 H2O (cf. OECD no. 201 guideline) - Conductivity:
- N/A
- Nominal and measured concentrations:
- Five different concentrations arranged in a geometric series with a spacing factor of 2 and a concurrent control were tested in the main experiment. The nominal test item concentrations were 6.25, 12.5, 25, 50 and 100 mg/L. The measured concentrations of Yellow LF 6911 varied between 93 and 107 % of the nominal concentration (i.e. within ± 20 %) during the experiment therefore the biological results are based on the nominal concentrations. In the untreated control group the test item was not detected.
- Details on test conditions:
- The test was performed with three replicates per test concentration and six replicates in the control group. The test was started (0 hours) by inoculation of 0.1 mL algal biomass (107 algal cells per mL) to 100 mL test item solution. The initial cell density was about 104 cells/mL, in each test flask. Volumes of 100 mL algal suspension per replicate were continuously shaken by a laboratory orbital shaker in 250 mL Erlenmeyer flasks. The test flasks were covered with air-permeable stoppers. The cell concentration was determined at 24, 48 and 72 hours after starting the test by manual cell counting using a microscopic method with a counting chamber. The cell morphology was examined in parallel.
- Reference substance (positive control):
- yes
- Remarks:
- For the evaluation of the reliability of the applied test system and the experimental conditions Potassium dichromate is tested at least twice a year.
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC20
- Effect conc.:
- >= 52 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- >= 15.9 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 6.25 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 37.5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 6.25 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Details on results:
- Validity of the Test
The cell density in the control cultures increased by a factor of 60.83 within 72 hours. This corresponds to a specific growth rate of 1.37 day-1.
The mean coefficient of variation (CV) for section-by-section specific growth rates (days 0-1, 1-2 and 2-3, for 72 h-tests) in the control cultures did
not exceed 35 % - CV for section-by-section growth rate day 0-1: 20.51 % - CV for section-by-section growth rate day 1-2: 13.22 % - CV for
section-by-section growth rate day 2-3: 5.28 % The mean coefficient of variation for section-by-section specific growth rates: 13.01 %.
The coefficient of variation of average specific growth rates during the whole test period (day 0-3) in the control cultures was 1.56 %.
All validity criteria were met, therefore the study can be considered as valid.
Analytical Results
Five different concentrations arranged in a geometric series with a spacing factor of 2 and a concurrent control were tested in the main experiment.
The nominal test item concentrations were 6.25, 12.5, 25, 50 and 100 mg/L. The measured concentrations of Yellow LF 6911 varied between 93
and 107 % of the nominal concentration (i.e. within ± 20 %) during the experiment therefore the biological results are based on the nominal concentrations.
In the untreated control group the test item was not detected.
Biological Results
The influence of the test item Yellow LF 6911 on the growth of Raphidocelis subcapitata is shown in Tables 1, 5-12 and Figures 1-3.
For the determination of the LOEC and NOEC, the calculated mean growth rates and yield at the test concentrations were tested on significant differences
to the control values by Bonferroni t-Test using TOXSTAT software. After the exposure period of 72 hours average specific growth rates and yield
were significantly different from the control group in the concentrations of 12.5, 25, 50 and 100 mg/L (see Tables 9 and 10). The test concentration
of 6.25 mg/L was determined as the 72-hour NOEC related to the growth rate and yield.
The 72-h ErC50 was determined to be > 100 mg/L (calculated as 500.6 mg/L). The 72-h EyC50 was determined to be 37.5 mg/L.
Microscopic Examinations
Shape of the algal cells No abnormal shape of algal cells was noticed in the control and in the concentrations of 6.25, 12.5, 25 and 50 mg/L during
the whole exposure period. : Thin and swollen cells were observed in the highest concentration of 100 mg/L during the test.
Cell density in control In the control the cell density has increased from nominal N= 1 × 104 cells/mL at the start of the test (0 hours) to
N= 60.83 × 104 cells/mL (mean value) after 72 hours. Thus, the algal growth in the control was high enough to pass the validity criteria in this assay. - Results with reference substance (positive control):
- For the evaluation of the reliability of the applied test system and the experimental conditions Potassium dichromate is tested at least twice a year. The date of the last study (Study number: 392-201-1333) with the reference item Potassium dichromate was: 01 – 04 March 2016. The 72h ErC50: 0.70 mg/L, (95 % confidence limits: 0.64 – 0.78 mg/L) The 72h EyC50: 0.39 mg/L, (95 % confidence limits: 0.36 – 0.43 mg/L)
- Reported statistics and error estimates:
- Mean values and standard deviations were calculated for each concentration at each observation period using Excel for Windows software.
For the determination of the LOEC and NOEC, the calculated mean growth rates and yield at the test concentrations were tested on significant differences
to the control values by Bonferroni t-Test (α = 0.05; 2-Tailed) using TOXSTAT software. The data were checked for normality by Chi-Square Test,
for homogeneity of variance by Hartley’s and Bartlett’s Test. For determination of the ErCx and EyCx values with 95 % confidence limits,
Probit analysis was performed using TOXSTAT software.
Any other information on results incl. tables
Analytical results:
Five different concentrations arranged in a geometric series with a spacing factor of 2 and a concurrent control were tested in the main experiment. The nominal test item concentrations were 6.25, 12.5, 25, 50 and 100 mg/L. The measured concentrations of Yellow LF 6911 varied between 93 and 107 % of the nominal concentration (i.e. within ± 20 %) during the experiment therefore the biological results are based on the nominal concentrations. In the untreated control group the test item was not detected.
Biological results
Algal Cell Concentrations (104cell/ mL) during the Test Period of 72 Hours and Yield
Concentration[mg/L] |
|
Number of Cells (× 104/mL) |
Yield |
|||
0 h |
24 h |
48 h |
72 h |
|||
Control |
|
1 |
3 |
12 |
63 |
62 |
|
1 |
2 |
10 |
54 |
53 |
|
|
1 |
4 |
12 |
62 |
61 |
|
|
1 |
3 |
11 |
64 |
63 |
|
|
1 |
3 |
12 |
59 |
58 |
|
|
1 |
3 |
10 |
63 |
62 |
|
Mean value |
1.00 |
3.00 |
11.17 |
60.83 |
59.83 |
|
SD |
0.00 |
0.63 |
0.98 |
3.76 |
3.76 |
|
6.25 |
|
1 |
3 |
11 |
49 |
48 |
|
1 |
3 |
11 |
58 |
57 |
|
|
1 |
3 |
10 |
57 |
56 |
|
Mean value |
1.00 |
3.00 |
10.67 |
54.67 |
53.67 |
|
SD |
0.00 |
0.00 |
0.58 |
4.93 |
4.93 |
|
12.5 |
|
1 |
3 |
10 |
39 |
38 |
|
1 |
3 |
11 |
40 |
39 |
|
|
1 |
3 |
11 |
39 |
38 |
|
Mean value |
1.00 |
3.00 |
10.67 |
39.33 |
38.33 |
|
SD |
0.00 |
0.00 |
0.58 |
0.58 |
0.58 |
|
25 |
|
1 |
3 |
9 |
39 |
38 |
|
1 |
3 |
10 |
30 |
29 |
|
|
1 |
3 |
9 |
31 |
30 |
|
Mean value |
1.00 |
3.00 |
9.33 |
33.33 |
32.33 |
|
SD |
0.00 |
0.00 |
0.58 |
4.93 |
4.93 |
|
50 |
|
1 |
2 |
9 |
32 |
31 |
|
1 |
3 |
10 |
27 |
26 |
|
|
1 |
2 |
8 |
29 |
28 |
|
Mean value |
1.00 |
2.33 |
9.00 |
29.33 |
28.33 |
|
SD |
0.00 |
0.58 |
1.00 |
2.52 |
2.52 |
|
100 |
|
1 |
2 |
6 |
21 |
20 |
|
1 |
1 |
7 |
19 |
18 |
|
|
1 |
1 |
6 |
20 |
19 |
|
Mean value |
1.00 |
1.33 |
6.33 |
20.00 |
19.00 |
|
SD |
0.00 |
0.58 |
0.58 |
1.00 |
1.00 |
The Specific Growth Rates during the Test Period of 72 Hours
Concentration[mg/L] |
|
Growth Rates (µ) |
||
0 – 24 h |
0 – 48 h |
0 – 72 h |
||
Control |
|
0.0458 |
0.0518 |
0.0575 |
|
0.0289 |
0.0480 |
0.0554 |
|
|
0.0578 |
0.0518 |
0.0573 |
|
|
0.0458 |
0.0500 |
0.0578 |
|
|
0.0458 |
0.0518 |
0.0566 |
|
|
0.0458 |
0.0480 |
0.0575 |
|
Mean |
0.0450 |
0.0502 |
0.0570 |
|
SD |
0.0092 |
0.0019 |
0.0009 |
|
6.25 |
|
0.0458 |
0.0500 |
0.0541 |
|
0.0458 |
0.0500 |
0.0564 |
|
|
0.0458 |
0.0480 |
0.0562 |
|
Mean value |
0.0458 |
0.0493 |
0.0555 |
|
SD |
0.0000 |
0.0011 |
0.0013 |
|
12.5 |
|
0.0458 |
0.0480 |
0.0509 |
|
0.0458 |
0.0500 |
0.0512 |
|
|
0.0458 |
0.0500 |
0.0509 |
|
Mean value |
0.0458 |
0.0493 |
0.0510 |
|
SD |
0.0000 |
0.0011 |
0.0002 |
|
25 |
|
0.0458 |
0.0458 |
0.0509 |
|
0.0458 |
0.0480 |
0.0472 |
|
|
0.0458 |
0.0458 |
0.0477 |
|
Mean value |
0.0458 |
0.0465 |
0.0486 |
|
SD |
0.0000 |
0.0013 |
0.0020 |
|
50 |
|
0.0289 |
0.0458 |
0.0481 |
|
0.0458 |
0.0480 |
0.0458 |
|
|
0.0289 |
0.0433 |
0.0468 |
|
Mean value |
0.0345 |
0.0457 |
0.0469 |
|
SD |
0.0098 |
0.0023 |
0.0012 |
|
100 |
|
0.0289 |
0.0373 |
0.0423 |
|
0.0000 |
0.0405 |
0.0409 |
|
|
0.0000 |
0.0373 |
0.0416 |
|
Mean value |
0.0096 |
0.0384 |
0.0416 |
|
SD |
0.0167 |
0.0019 |
0.0007 |
Growth Rates (µ) and Percentage Inhibition of µ during the Test Period
Concentration[mg/L] |
Growth Rates (µ)and % Inhibition ofµ |
|||||
0–24 h |
0–48 h |
0–72 h |
||||
µ |
% |
µ |
% |
µ |
% |
|
Control |
0.0450 |
0.0 |
0.0502 |
0.0 |
0.0570 |
0.0 |
6.25 |
0.0458 |
-1.8 |
0.0493 |
1.8 |
0.0555 |
2.6 |
12.5 |
0.0458 |
-1.8 |
0.0493 |
1.8 |
0.0510 |
10.6 |
25 |
0.0458 |
-1.8 |
0.0465 |
7.4 |
0.0486 |
14.8 |
50 |
0.0345 |
23.2 |
0.0457 |
9.0 |
0.0469 |
17.8 |
100 |
0.0096 |
78.6 |
0.0384 |
23.5 |
0.0416 |
27.1 |
Yield (Y) and Percentage Inhibition of Y during the Test Period
Concentration[mg/L] |
Yield y and % Inhibition of y |
|
0–72 h |
||
y |
% |
|
Control |
59.83 |
0.0 |
6.25 |
53.67 |
10.3 |
12.5 |
38.33 |
35.9 |
25 |
32.33 |
46.0 |
50 |
28.33 |
52.6 |
100 |
19.00 |
68.2 |
Results of the statistical evaluation based on the growth rates (Bonferroni t-Test)
Concentration[mg/L] |
Growth Rates(0–72 h) |
||
Calculated t-value |
Difference from Control |
Significance |
|
6.25 |
1.8242 |
0.0014 |
n.s. |
12.5 |
7.5693 |
0.0060 |
* |
25 |
10.5886 |
0.0084 |
* |
50 |
12.7273 |
0.0101 |
* |
100 |
19.3950 |
0.0154 |
* |
Minimal significant difference |
0.0023 |
||
Percentage of control |
4.1 |
*: statistically significantly different from the control(Bonferroni t-Test; 2 Tailed;a= 0.05; df = 5.15)
n.s.: statistically not significantly different from the control (Bonferroni t-Test; 2 Tailed;a= 0.05; df = 5.15)
Results of the statistical evaluation based on the Yield (Bonferroni t-Test)
Concentration[mg/L] |
Growth Rates(0–72 h) |
||
Calculated t-value |
Difference from Control |
Significance |
|
6.25 |
2.4934 |
6.1667 |
n.s. |
12.5 |
8.6932 |
21.5000 |
* |
25 |
11.1192 |
27.5000 |
* |
50 |
12.7366 |
31.5000 |
* |
100 |
16.5104 |
40.8333 |
* |
Minimal significant difference |
7.2878 |
||
Percentage of control |
12.2 |
*: statistically significantly different from the control (Bonferroni t-Test; 2 Tailed;a= 0.05; df = 5.15)
n.s.: statistically not significantly different from the control (Bonferroni t-Test; 2 Tailed;a= 0.05; df = 5.15)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Parameter (0-72 h) Growth rate (µ) [mg/L] Yield (y) [mg/L]
Calculation based on measured concentrations
EC10 15.9 3.4
95 % conf. limits 9.9 – 25.8 2.0 – 5.8
EC20 52.0 7.7
95 % conf. limits 34.4 – 78.8 5.4 – 11.1
EC50 > 100 (500.6 calculated) 37.5
95 % conf. limits > 100 (157.5 – 1590.7 calculated) 29.8 – 47.1
NOEC 6.25 6.25
LOEC 12.5 12.5
- Executive summary:
Exponentially-growing cultures of Raphidocelis subcapitata were exposed to the test item under defined conditions. The algal growth in relation to a control culture was determined over a fixed test period of 72 hours and, thus, over several algal generations. The test design included three replicates at each test concentration and six replicates for the untreated control. The alga cell concentration was approximately 104 cells/mL at the start of the test in all of the test cultures. Glass flasks with total capacity of 250 mL were used as test vessels. The volume of the test liquid in the vessels was 100 mL. The alga cell concentration was determined by manual cell counting by microscope in each testing flask during the 72-hour test, in 24-hour intervals.
EC10, EC20, EC50, NOEC and LOEC for both response variables (i.e. average specific growth rate and yield).
Parameter (0-72 h) Growth rate (µ) [mg/L] Yield (y) [mg/L]
Calculation based on measured concentrations
EC10 15.9 3.4
95 % conf. limits 9.9 – 25.8 2.0 – 5.8
EC20 52.0 7.7
95 % conf. limits 34.4 – 78.8 5.4 – 11.1
EC50 > 100 (500.6 calculated) 37.5
95 % conf. limits > 100 (157.5 – 1590.7 calculated) 29.8 – 47.1
NOEC 6.25 6.25
LOEC 12.5 12.5
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)
Čeprav agencija ECHA veliko spletnega gradiva objavlja v vašem jeziku, je ta stran deloma še vedno v angleščini. Več informacij o večjezikovni praksi agencije.
Dobrodošli na spletišču agencije ECHA Vsebina na tej strani ni v celoti podprta z brskalnikom Internet Explorer 7 (in starejšimi različicami). Prosimo, nadgradite vaš brskalnik Internet Explorer na novejšo različico.
Ta stran uporablja piškotke za zagotavljanje najboljše možne uporabniške izkušnje na našem spletišču.
Preberite več o tem, kako uporabljamo piškotke.