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EC number: 603-525-9 | CAS number: 131860-97-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Dermal, LD50, rat >2000 mg/kg bw (Robinson)
Inhalation, LC50, rat, 1 hour >1890 mg/m3 (Parr-Dobrzanski) extrapolated in a four- hour inhalation LC50 >470 mg/m3 calculated.
Key value for chemical safety assessment
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral
No oral acute toxicity data are reported for the test substance. Since the inhalation and dermal routes are much more likely to occur in human exposure, and the toxicity determined by either route is insignificant to slight, an experimental determination of the oral LD50 is considered unnecessary for classification and labelling.
Inhalation
For this endpoint the summarised result of one study (CTL, Parr-Dobrzanski) is available, which was conducted under GLP.
One hour of exposure to an atmospheric aerosol concentration of 1890 mg/m3 (mass median aerodynamic diameter 4.86 micrometer) caused no deaths and only slight, transient signs of irritation, therefore the on-hour inhalation LC50 is >1890 mg/m3.
While the full study report is not available, the results are sufficiently detailed and unambiguous as to be reliable with some restrictions.
Since the goal of the study was the assessment of the short-term inhalation hazard, an exposure duration of only one hour was chosen. For aerosols, which are normally not secondarily exhaled, an approximate extrapolation to the usual 4-hour exposure can be based on Haber's rule (Miller FJ, Schlosser PM & Janszen DB (2000): Haber's rule: a special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint, Toxicology 149: 22-34). This calculation results in a four- hour inhalation LC50 >470 mg/m3.
Dermal
For this endpoint the summarised result of one study (CTL, Robinson) is available, which was conducted under GLP. While the full study report is not available, the results are sufficiently detailed and unambiguous as to be suitable for classification and labeling.
It reported no mortalities and no significant signs of toxicity at the limit dose of 2000 mg/kg bw. A dermal LD50 > 2000 mg/kg bw is taken forward for classification and labelling.
Justification for classification or non-classification
The available data on Acute Dermal Toxicity are considered reliable and suitable for classification and labeling.
The value for the Acute Dermal Toxicity, LD50 > 2000 mg/kg bw does not lead to the classification of the substance, according to the criteria in Directive 2001/59/EC, Annex VI, 3.2 and according to the criteria for classification under Regulation (EC) No. 1272/2008, Annex I, Part 3, 3.1.2.
No deaths or adverse clinical effects were observed in the test for the Acute Inhalation toxicity. The result of the test gives a LC0> 1.89 mg/L in 1-hour exposure and the extrapolation applying the Haber’s law gives a LC0>0.47 mg/L in 4-hours exposure.
Since no signs of clinical effects up to the upper limit tested were noted, the result indicates that the LC50 value must be significantly higher than the highest concentration tested. Because the study was performed with a maximum concentration < 5 mg/L, and extrapolated from 1-hour exposure data, the result is not considered to be conclusive for classification and labeling.
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