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Diss Factsheets
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EC number: 807-422-1 | CAS number: 66918-01-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Assessment based on physicochemical properties
- Adequacy of study:
- weight of evidence
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: in accordance with (EC) No 1907/2006, Annex VIII, 8.8. column I
- Objective of study:
- absorption
- bioaccessibility (or bioavailability)
- distribution
- excretion
- metabolism
- toxicokinetics
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The toxicokinetic behaviour of the substance is assessed to the extent that can be derived from the relevant available information.
- GLP compliance:
- no
- Specific details on test material used for the study:
- no physical test material used for the assessment
- Conclusions:
- The toxicokinetic behaviour of the substance was assessed based on its physicochemical properties.
A low bioaccessibility by inhalative and dermal route is likely.
For oral route, no information is present and by default 100% is assumed.
Due to the high log Pow, the substance has a high potential for bioaccumulation.
Reference
Absorption:
Based on above data the substance is unlikely to be absorbed through the skin in relevant amounts (none of the following apply: molecular weight < 500 g/Mol, -1 < log POW< 4, see EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRETORATE-GENERAL: Guidance Document on Dermal Absorpiton Sanco/222/2000 rev. 7 19 March 2004).
For exposure assessments a value of 10 % of absorption after dermal exposure may be appropriate.
Uptake by inhalation after evaporation is unlikely, the substance is a liquid at room temperature and has a very low vapour pressure.
For exposure assessments a default value of 10 % of absorption via inhalation may be appropriate.
The absorption after oral ingestion cannot be calculated due to lack of data; by default absorption of 100 % may be appropriate, until specific data will be available.
Distribution:
The substance is very lipophilic and Protein binding may be relevant. The low water solubility may lead to a high distribution volume. Therefore distribution to specific organs is depending not only on blood flow. Crossing of membrane barriers like the Blood/Brain barrier seems unlikely giving the molecular weight and the high lipophilicity of the substance.
Metabolism and Excretion:
The substance does contain ester functions which are likely target of Phase I Esterase(s). The resulting metabolites do have functional groups ready for Metabolism Phase II reactions. The C18-Alcohol can undergo conjugation to increase the water solubility while malate is a common metabolite in physiological reactions.
Giving the low water solubility and high lipophilicity, Excretion via faeces is rather likely.
Excretion by inhalation and urinary excretion is rather unlikely.
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- high bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 10
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.