Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-424-2 | CAS number: 578-54-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
2-ethylaniline has got a not negligible acute toxicity: oral LD50 rat = 1260 mg/kg/bw, dermal LD50 rabbit = 840 mg/kg/bw and inhalation LD0 rat = 1.07 mg/l (220 ppm)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 260 mg/kg bw
- Quality of whole database:
- Data from reliable source (Chemical Information Profile for Alkylaniline NTP 2009)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Data from reliable source (Chemical Information Profile for Alkylaniline NTP 2009)
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 840 mg/kg bw
- Quality of whole database:
- Data from reliable source (Chemical Information Profile for Alkylaniline NTP 2009)
Additional information
Oral exposure:
As reported in Chemical Information Profile for Alkylaniline NTP 2009 with reference to database ChemIDplus and to Jacobsen, Toxicology and Applied Pharmacology. Vol. 22, Pg. 153, 1972 LD50 oral rat for 2-ethylaniline is 1260 mg/kg/bw. At this concentration somnolence (general depressed activity); cyanosis in the lungs, thorax, or respiratory tract; blood changes in spleen were observed in rats. Based on this data and according to the CLP Regulation (EC n. 1272/2008) the classification H302 (acute oral toxicity cat.4) is proposed for 2-ethylaniline.
Inhalation exposure:
As reported in Chemical Information Profile for Alkylaniline NTP 2009 with reference toU.S. EPA (Environmental Protection Agency). 2006. High Production Volume (HPV) Challenge Program. Robust Summaries & Test Plans: Ring Substituted Anilines Category. Cover letter (dated May 4, 2006), test plan, and robust summaries submitted to the U.S. EPA Chemical Right-to-Know Program by Dr. Len Sweet of Albemarle Corporation, Baton Rouge, LA, pp.121 LD0 inhalation rat for 2-ethylaniline is 1.07 mg/l (220 ppm). No indication regarding the convertion beetween these two values is reported. This data is conclusive but not sufficient for classification.
Dermal exposure:
As reported in Chemical Information Profile for Alkylaniline NTP 2009 with reference to U.S. EPA (Environmental Protection Agency). 2006. High Production Volume (HPV) Challenge Program. Robust Summaries & Test Plans: Ring Substituted Anilines Category. Cover letter (dated May 4, 2006), test plan, and robust summaries submitted to the U.S. EPA Chemical Right-to-Know Program by Dr. Len Sweet of Albemarle Corporation, Baton Rouge, LA, pp.121 LD50 dermal rabbit for 2-ethylaniline is 840 mg/kg/bw. Based on this data and according to the CLP Regulation (EC n. 1272/2008) the classification H311 (acute dermal toxicity cat.3) is proposed for 2-ethylaniline.
In this summary are reported data owner studies published by NTP. They have been used for precautionary purposes and for the benefit of the human health .Those data are not necessary for the registration of the target substance which is used exclusively as isolated and transported intermediate, but they can be very helpful for a better definition of the toxicological property of the substance. No other use and no commercial advantage will derive from the use of those data.
Justification for classification or non-classification
2-ethylaniline has got a not negligible acute toxicity: oral LD50 rat = 1260 mg/kg/bw, dermal LD50 rabbit = 840 mg/kg/bw and inhalator LD0 rat = 1.07 mg/l (220 ppm). Based on these data and according to the CLP Regulation (EC n. 1272/2008) the classification H302 (acute oral toxicity cat.4) and H311 (acute dermal toxicity cat.3) is proposed for 2-ethylaniline.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.