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Diss Factsheets
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EC number: 473-780-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 5 February to 7 February 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, GLP compliant; no restrictions, fully adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Water samples were taken from the solvent control and each replicate test vessel at 0 and 48 hours for quantitative analysis.
Two samples of the solvent control and each replicate were taken at each occasion. One sample was analysed untreated and one sample after centrifugation (40000 g for approximately 30 minutes). Further samples (in duplicate) were taken and stored at approximately -20°C for further analysis if necessary.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- During the definitive test samples of the test preparations were analysed untreated and following centrifugation at 40000 g for 30 minutes. The untreated samples indicated the total amount of test material present in the test preparations whilst the centrifuged samples indicated the amount of soluble and hence bioavailable test material present.
Analysis of the untreated test preparations throughout the test showed measured test concentrations of 101% to 126% of the nominal value, indicating that the test system was correctly dosed. Analysis of the freshly prepared centrifuged test preparations at 0 hours showed measured test concentrations of 69% to 70% of the nominal value. Analysis of the centrifuged samples at 48 hours showed measured test concentrations of 46% to 51% of the nominal value. The low measured concentrations in the centrifuged samples at both 0 and 48 hours indicated that not all the test material present was dissolved. There was also a slight decline in the measured test concentrations of the centrifuged test samples over the test period, indicating that the soluble test material may have also been unstable in the test diluent. The inconsistency with the water solubility value of 0.00151 mg/l from the study to determine the water solubility of the test material (Safepharm Laboratories Project Number 0656/0322) was considered to be due to differences in the diluents used, as reconstituted water used in the Daphnia magna test had a far greater dissolved salt/mineral concentration than glass double distilled water used for the water solubility test which affected the water solubility.
Given that lower values were shown for the centrifuged test material preparations and a slight decline was shown in these measured test concentrations over the test period it was considered justifiable to base the results on the geometric mean measured test concentrations of the centrifuged test media in order to give a "worst case" analysis of the data.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Adult Daphnia were maintained in polypropylene vessels containing approximately 2 litres of reconstituted water in a temperature controlled room at approximately 20°C. The lighting cycle was controlled to give a 16 hours light and 8 hours darkness cycle with 20 minute dawn and dusk
transition periods. Each culture was fed daily with a suspension of algae (ChIarella sp.). Culture conditions ensured that reproduction was by parthenogenesis. Gravid adults were isolated the day before initiation of the test, such that the young daphnids produced overnight were less than 24 hours old. These young were removed from the cultures and used for testing. The diet and diluent water are considered not to contain any contaminant that would affect the integrity or outcome of the study.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- None
Test conditions
- Hardness:
- 250 mg/l as CaCO3
- Test temperature:
- Approximately 20ºC
- pH:
- 7.8 - 8.0
- Dissolved oxygen:
- 8.7 - 8.9 mg O2/l
- Nominal and measured concentrations:
- Nominal: 0.0015 mg/l
Mean measured: 0.00087 mg/l
See also 'Details on test solutions' - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: covered
- Material, size, headspace, fill volume: 250 ml glass jars
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water
OTHER TEST CONDITIONS
- Adjustment of pH: None
- Photoperiod: 16 hours light, 8 hours dark
SOLVENT CONTROL
100 µl/l DMF
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortality, after 24 and 48 hours - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.001 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.001 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Results with reference substance (positive control):
- Sensitivity to control substance
EC50 (24 h) : 1.2 mg/l
EC50 (48 h) : 0.85 mg/l
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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