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EC number: 202-885-0 | CAS number: 100-74-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity: oral:
A K1 acute oral toxicity test with NEM was performed in male and female rats according to OECD Guideline 401. The LD50 was determined to be between 1500-2000 mg/kg bw (males). Therefore the substance was determined to be classified as acute oral category 4 toxicant.
Acute toxicity: dermal:
A K1 acute dermal toxicity test with NEM was performed in male and female New Zealand White rabbits according to a guideline similar to OECD Guideline 402. The dermal LD50 for NEM was determined to be 1980 mg/kg.Therefore the substance was determined to be classified as acute dermal category 4 toxicant.
Acute toxicity: inhalation:
No study was performed. An acute inhalation study is not performed as key studies with administration via two other routes was performed.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 500 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 980 mg/kg bw
Additional information
Acute toxicity: oral
In a K1 acute oral toxicity study according to OECD guideline 401, rats (5 animals/sex/dose) were given 4 -ethylmorpholine, by oral gavage at 0, 500, 1000, 1500 or 2000 mg/kg bw. Death was observed in three males and two females at 2000 mg/kg bw, one male at 1500 mg/kg bw, and one female at 1000 mg/kg bw. Most of males and females at 1000 mg/kg bw and higher showed tonic and/or clonic convulsions and decreased locomotor activity. The body weight gain of both sexes was suppressed at 1500 mg/kg bw and higher. No abnormalities were found at necropsy in surviving animals, although edema and red area in the glandular stomach were found in the dead animals.
Acute toxicity: dermal
A K1 study was performed with NEM, in male and female New Zealand White rabbits (5 animals per sex per dose) according to the OECD guideline 402. NEM was dosed via occlusive application during 24 hours at dose levels of 1000, 2000 and 3000 mg/kg, followed by a 14 -day observation period. At 1000 mg/kg bw dose, none of the animals died; at 2000 mg/kg 7 out of 10 animals died, and at 3000 mg/kg all animals died (10 out of 10). Clinical signs observed included decreased activity and necrosis of the skin at the application sites. Necropsy revealed irritation of the underlying muscle at the application site. No visible lesions were observed in any animal at terminal necropsy. The acute dermal LD50 in males and females was determined to be 1980 mg/kg. Therefore the substance is considered to be classified as acute dermal category 4 toxicant.
Acute toxicity: inhalation
No study is available with the test substance NEM. This is deemed not required as key studies via two other routes of administration are available.
Justification for selection of acute toxicity – oral endpoint
Three reliable studies available, all concluding category 4 classification.
Justification for selection of acute toxicity – dermal endpoint
Only one reliable study available
Justification for classification or non-classification
Based on the available data NEM is classified for acute oral toxicity category 4 and acute dermal category 4 according to the CLP criteria.
The route of inhalation was not evaluated (waiver).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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