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EC number: 237-525-1 | CAS number: 13826-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Test substance 3-Phenoxybenzylalcohol (CAS No :13826-35-2) was eye irritant to New Zealand white rabbits whereas the other study indicate that it is not irritating to skin when applied to New Zealand white rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from QSAR Toolbox version 3.3
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- The prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- 24 Hrs
- Observation period:
- 24 Hrs
- Number of animals:
- no data
- Details on study design:
- no data
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 Hr
- Reversibility:
- no data
- Remarks on result:
- other: Irritation parameter: Negative
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance 3-Phenoxybenzyl alcohol was estimated to be non-irritating to the skin of rabbits.
- Executive summary:
The test substance3-Phenoxybenzyl alcoholwas estimated to be non-irritating to the skin of rabbits.
Considering the CLP criteria for classification of substances, it is concluded that3-Phenoxybenzyl alcoholis not likely to be classified as skin irritant.
Reference
Estimation method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b" ) and ("c" and "d" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Benzyl Alcohols by Aquatic toxicity classification by ECOSAR
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as High (Class III) by Toxic hazard classification by Cramer (original) ONLY
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= 2.59
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= 4.68
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from online Chemical Repository Database
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Primary eye irritation study was performed on New Zealand White rabbits for 7 days.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: The Ethyl Corporation, Ferndale, Michiga
- Age at study initiation: No data available
- Weight at study initiation: 2045 to 2330 grams
- Fasting period before study: No data available
- Housing: In hanging wire-mesh cages
- Diet (e.g. ad libitum): Purina Rabbit Chow(ad libitum)
- Water (e.g. ad libitum): Water(ad libitum)
- Acclimation period:
Or Test Tissue
- Source: not applicable
- Type: not applicable
- Acclimation : not applicable
- Housing conditions: not applicable
ENVIRONMENTAL CONDITIONS
- Temperature (°C): in temperature controlled quarters
- Humidity (%):in humidity controlled quarters
- Air changes (per hr):No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available - Vehicle:
- not specified
- Controls:
- other: The left eye served as the untreated control for each rabbit.
- Amount / concentration applied:
- 0.1 milliliter of the undiluted test material
- Duration of treatment / exposure:
- The 3 rabbits in Group I did not receive a washout. The 3 rabbits in Group II received a 300 ml distilled water washout 5 minutes following instillation. This washout was accomplished over a one minute period.
- Observation period (in vivo):
- 24 hours following instillation,48 hours,72 hours,7 days
- Number of animals or in vitro replicates:
- 6 animals(3 male and 3 female)
- Details on study design:
- TEST SITE
- Area of exposure: not applicable
- % coverage: not applicable
- Type of wrap if used: not applicable
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The 3 rabbits in Group II received a 300 ml distilled water washout 5 minutes following instillation. This washout was accomplished over a one minute period. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Corneal luster was observed in unwashed eye.
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Iris irritation was observed in unwashed eye.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Chemosis was observed in unwashed eye.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: corneal luster was observed in washed eyes
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Iridal irritation was observed in washed eyes
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The end point for 3-Phenoxybenzylalcohol (CAS No :13826-35-2) on New Zealand white rabbits was found to be for
Group I (Unwashed Eyes): A possible primary eye irritant.
Group II (washed Eyes): A probable primary eye irritant. - Executive summary:
Eye irritation experiment was performed onNew Zealand white rabbits. 3 males and 3 female of weight 2045 and 2330 grams were used in this study. The rabbits were individually housed in hanging wire-mesh cages in temperature and humidity controlled quarters maintained in accordance with the recommendations contained in H.E.W. Publication No. 74-23 (N.I.H.) entitled "Guide for the Care and Use of Laboratory Animals".
The eyes of each rabbit were examined with ultraviolet light after instillation of one drop of 2.0 percent sodium fluorescein solution. The 6 rabbits were divided into 2 groups of 3 rabbits each and received 0.1 ml of undiluted test material.
The test material was placed on right eye and left eye was used as a control.Group I group did not receive washout and group II 3 rabbits received a 300 ml distilled water washout 5 minutes following instillation and observed on 24, 48, 72 hours and 7 days.
So, according to the grading system result found that concluded thatend point for 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) on New Zealand white rabbits was found to be for Group I (Unwashed Eyes): A possible primary eye irritant.
Group II (washed Eyes): A probable primary eye irritant.
Reference
For Group 1:Unwashed eye
Eye Irritation in the Albino rabbit
|
Average score (range) |
|||
|
Period |
|||
Area |
24 hours |
48 hours |
72 hours |
Days 7 |
Cornea |
0.5 |
0.5 |
0.5 |
0 |
Iris |
0 |
0 |
0 |
0 |
Conjunctivae |
0.6 |
0 |
0.6 |
0 |
Total score |
1.1 |
0.5 |
1.1 |
0 |
For Group 2: Washed eye
Eye Irritation in the Albino rabbit
|
Average score (range) |
|||
|
Period |
|||
Area |
24 hours |
48 hours |
72 hours |
Days 7 |
Cornea |
2.5 |
3.5 |
2.5 |
0 |
Iris |
0 |
0 |
0 |
0 |
Conjunctivae |
1.4 |
0.6 |
0.6 |
0 |
Total score |
3.9 |
4.1 |
3.1 |
0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / corrosion:
The test substance3-Phenoxybenzyl alcoholwas estimated to be non-irritating to the skin of rabbits.
Considering the CLP criteria for classification of substances, it is concluded that 3-Phenoxybenzyl alcoholis not likely to be classified as skin irritant.
Eye irritation:
Eye irritation experiment was performed onNew Zealand white rabbits. 3 males and 3 female of weight 2045 and 2330 grams were used in this study. The rabbits were individually housed in hanging wire-mesh cages in temperature and humidity controlled quarters maintained in accordance with the recommendations contained in H.E.W. Publication No. 74-23 (N.I.H.) entitled "Guide for the Care and Use of Laboratory Animals".
The eyes of each rabbit were examined with ultraviolet light after instillation of one drop of 2.0 percent sodium fluorescein solution. The 6 rabbits were divided into 2 groups of 3 rabbits each and received 0.1 ml of undiluted test material.
The test material was placed on right eye and left eye was used as a control.Group I group did not receive washout and group II 3 rabbits received a 300 ml distilled water washout 5 minutes following instillation and observed on 24, 48, 72 hours and 7 days.
So, according to the grading system result found that concluded thatend point for 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) on New Zealand white rabbits was found to be for Group I (Unwashed Eyes): A possible primary eye irritant.
Group II (washed Eyes): A probable primary eye irritant.
Justification for selection of skin irritation / corrosion endpoint:
The endpoint for the 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) for New Zealand white rabbits were found to be non- skin irritating.
Justification for selection of eye irritation endpoint:
The end point for 3-Phenoxybenzylalcohol (CAS No :13826-35-2) on New Zealand white rabbits was found to be for
Group I (Unwashed Eyes): A possible primary eye irritant.
Group II (washed Eyes): A probable primary eye irritant.
Justification for classification or non-classification
On the basis of available information, the substance 3-Phenoxybenzylalcohol (CAS NO. 13826-35-2) is likely to be irritating to eyes of rabbits but not irritating to skin of rabbit and is therefore classified as "Not Irritating" to skin and “Irritating “to eye as per the CLP criteria.
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